微纳米马达的运动控制及其在精准医疗中的应用  

Controlling the micro/nanomotors motion and their application in precision medicine

作　　者：刘聪慧[1] 黄金荣[1] 宋永超[1] 许太林 张学记[1] Conghui Liu Jinrong Huang Yongchao Song Tailin Xu Xueji Zhang(Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China)

机构地区：[1]北京科技大学生物工程与传感技术研究中心,北京100083

出　　处：《中国科学：化学》2017年第1期29-39,共11页SCIENTIA SINICA Chimica

基　　金：国家自然科学基金(编号:21475009;21475008)资助项目

摘　　要：人工微纳米马达是模仿自然界中的生物马达制备而成的微纳尺度动力装置,具有稳定性高、制备简单、可批量生产等优点,在生物医学领域有广阔的应用前景.本文详细阐述了磁能、电能、声能、光能及热能等多种微纳米马达的运动控制方式,总结了其在核酸、蛋白质、细胞以及细菌等的装载、运输、释放和检测方面的研究进展,并讨论了其在精准医疗领域面临的挑战和未来的发展方向.Synthetic micro/nanomotors are small devices at the micro/nanoscale fabricated by imitating the biological motors. Due to the distinguish advantages including good stability, simple preparation and mass production, micro/nanomotors have been a promising tool in precision medicine. In this review, we focus on utilizing the manipulation methods such as magnetic, electrochemical, acoustic, light to precisely control the direction and speed of micro/nanomotors, and detail the application of controlled micro/nanomotors in precision medicine including cargo transportations, targeted drug/proteins/nucleic delivery, cell and bacteria manipulation. The practical application potentials of precisely controlling micro/nanomotors are also discussed.

关 键 词：微纳米马达 运动控制 精准医疗 

分 类 号：R318[医药卫生—生物医学工程]