老年乳腺癌组织中表皮生长因子受体2、雌激素受体、孕酮受体、P53和Ki67的表达及其临床意义  

Expression level and its clinical significance of human epidermal growth factor receptor 2, estrogen receptor, progesterone receptor, P53 and Ki-67 in breast cancer tissues of elderly patients

作　　者：方谭玮[1] 俸瑞发[1] 陈威[1] 

机构地区：[1]桂林医学院第二附属医院乳腺外科,541100

出　　处：《中华老年医学杂志》2017年第2期173-176,共4页Chinese Journal of Geriatrics

摘　　要：目的研究老年乳腺癌组织中表皮生长因子受体2（C-erbB-2）、雌激素受体（ER）、孕酮受体（PR）、P53及Ki67的表达及其临床意义。方法采用免疫组化（S-P方法）检测103例老年乳腺癌患者组织中的人C-erbB-2、ER、PR、P53及Ki67的表达，分析其与肿瘤大小、淋巴结转移和临床分期的关系。结果103例乳腺癌中C-erbB-2、ER、PR、Ki67和P53蛋白阳性表达率分别为17．5％（18／103）、64．1％（66／103）、54．4％（56／103）、70．9％（73／103）和66．0％（68／103）；C-erbB-2和P53阳性表达率与临床分期、有无淋巴结转移有关（P〈0．05）；Ki67阳性表达率与临床分期有关（P〈0．05），与肿瘤大小和有无淋巴结转移无关（P〉0．05）；C-erbB-2、P53、ER和PR阳性表达率与肿瘤大小无关（P〉0．05）。结论C-erbB-2、P53、Ki67阳性表达可作为评价老年乳腺癌发生、发展的生物学指标，检测C-erbB-2、ER、PR、P53和Ki67可有助于判断老年乳腺癌患者腋窝淋巴结转移和临床分期。Objectives To investigate the expression level and its clinical significance of human epidermal growth factor receptor 2 （C-erbB-2）, estrogen receptor （ ER）, progesterone receptor （ PR）, Ki67 and P53 in breast cancer tissues of elderly patients. Methods The expressions of C-erbB-2, ER, PR, Ki67 and P53 in 103 specimens of breast cancer tissues were assessed by immunohistochemistry（S-P）, and their relationships with clinicopathological factors including tumor size,lymph node metastasis status and clinical stages were statistically analyzed. Results The positive rate of C-erbB-2,ER,PR,Ki67 and P53 in 103 cases was 17.5%（18/103）,64. 1%（66/103）, 54.4%（56/103） ,70.9% （73/103）and 66.0%（68/103）,respectively. The positive expression rates of C-erbB-2 and P53 were correlated with clinical stages and lymph node metastasis status（P〈0.05）. The positive expression rate of Ki67 was correlated with clinical stages（P〈0.05）, but not correlated with tumor size and lymph node metastasis status（P〉0.05）. The positive expression rates of C-erbB- 2 ,P53 ,ER and PR were irrelevant to tumor size（P〉0.05）. Conclusions The expression of C-erbB- 2,ER,PR,Ki67 and P53 could be biological markers for estimating the occurrence and progression of elderly breast cancer. Detection of C-erbB-2, ER, PR, Ki67 and P53 may help judge the clinical stages and lymph node metastasis status in elderly patients with breast cancer.

关 键 词：乳腺肿瘤 肿瘤标记 生物学 

分 类 号：R737.9[医药卫生—肿瘤]