三阴性乳腺癌化疗相关认知障碍与年龄的相关性研究  

Relationship between chemotherapy-induced cognitive impairment and age in triple negative breast cancer

作　　者：张从军[1] 丁琦[1] 宁洁[1] 钱勇[1] 李敏[1] 程怀东[2] 

机构地区：[1]安徽医科大学第一附属医院肿瘤内科,合肥230022 [2]安徽医科大学第二附属医院肿瘤中心,合肥230601

出　　处：《安徽医科大学学报》2017年第1期109-112,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81372487);安徽医科大学校科研基金资助项目(编号:2015xkj101)

摘　　要：目的探讨三阴性乳腺癌化疗相关认知障碍(CICI)与年龄的相关性。方法纳入不同年龄段乳腺癌化疗患者和健康对照组各90例,其中三阴性乳腺癌(三阴组)及非三阴性乳腺癌(非三阴组)各45例,分为青年、中年、老年组各30例,其中三阴组、非三阴组各年龄分组均为15例。分别进行简易精神状态检查表(MMSE)及回顾性记忆(RM)和前瞻性记忆(PM)问卷调查。结果乳腺癌组与健康对照组MMSE、RM量表、PM量表评分相比差异均有统计学意义(P<0.000 1)。乳腺癌组中,MMSE评分与年龄呈负相关性(r=-0.675,P<0.000 1),RM量表、PM量表评分与年龄呈正相关性(r=0.500、0.429,P<0.000 1)。三阴组、非三阴组在MMSE、RM量表、PM量表中差异均有统计学意义(P<0.05)。三阴组、非三阴组中,其青年组、中年组、老年组3组间MMSE、RM量表、PM量表评分差异均有统计学意义(P<0.000 1)。在青年组中,三阴组与非三阴组相比,MMSE、RM量表、PM量表评分差异均有统计学意义(P<0.000 1)。而中、老年组中,三阴组与非三阴组相比,MMSE、PM量表、RM量表评分差异均无统计学意义。多元Logistic回归分析结果显示:三阴性乳腺癌(OR=3.763,P=0.005)、年龄(OR=1.097,P<0.000 1)为乳腺癌患者发生认知障碍的危险因素。结论乳腺癌化疗患者均出现不同程度的认知障碍,与非三阴性乳腺癌患者相比,三阴性乳腺癌患者认知障碍较严重,其差异主要以青年患者为主,同时三阴性乳腺癌与年龄均为乳腺癌CICI的危险因素。Objective To explore correlation bwtween age and chemotherapy-induced cognitive impairment （CICI） in triple negative breast cancer （TNBC） patients. Methods Minimum Mental State Examination （MMSE） and questionnaires of retrospective memory （RM） and prospective memory （PM） were performed in 90 breast cancer patients with chemotherapy treatment and 90 health controls. All subjects were divided into TNBC group and non-TN-BC group（45 cases for each）. And all subjects were divided into three age group on average （young and middleaged group, elderly group） , each age group were consisted with 15 TNBC cases and 15 non-TNBC cases. Results Compared with the healthy controls, MMSE and questionnaires of RM and PM in breast cancer patients with chemotherapy treatment had statistical significance （P 〈 0. 0001 ）. Linear correlation analysis found that MMSE in breast cancer patients with chemotherapy treatment was negatively correlated with age（ r = -0. 675 ,P 〈 0. 0001 ） , and questionnaires of RM and PM were positively correlated with age （ r = 0. 500,0. 429, P 〈 0. 0001 ）. MMSE and questionnaires of RM and PM all had statistic significance（P 〈 0.05 ） between TNBC group and non-TNBC group. There was statistical significance of MMSE and questionnaires of RM and PM in young and middle-aged group and elderly group（P 〈0. 0001） in both TNBC group and non-TNBC group. In young-aged group, compared with non- TNBC group, MMSE and questionnaires of RM and PM in TNBC group had statistic significance （P 〈 0. 05 ）. While middle-aged group and elderly group did not see the same results in young-aged group. Logistic regression analysis revealed that TNBC （OR = 3. 763 ,P =0. 005）, age （OR = 1. 097, P 〈0. 000 1 ） were the risk factors for CICI of breast cancer. Conclusion Breast cancer patients with chemotherapy treatment all undergo varying degrees of cognitive impairment. Compared with non-TNBC patients,TNBC patients have worse cognitive impairment, especially in youn

关 键 词：乳腺癌 化疗相关认知障碍 年龄 三阴性乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]