3DCRT联合TP方案同步放化疗治疗Ⅲ期非小细胞肺癌的临床疗效  

Clinical efficacy of 3DCRT combined with docetaxel / paclitaxel plus cisplatin( TP) concurrent chemoradiotherapy for Ⅲ stage non- small cell lung cancer

作　　者：周后龙 杨艳 李前文 张闯 韦淑贞 

机构地区：[1]解放军第八二医院肿瘤科,江苏淮安223001

出　　处：《现代肿瘤医学》2017年第6期902-904,共3页Journal of Modern Oncology

基　　金：国家高技术研究发展计划(863计划)基金资助(编号:2014AA020901)

摘　　要：目的:分析3DCRT联合TP方案同步放化疗治疗Ⅲ期非小细胞肺癌的临床疗效分析。方法:选取2010年1月-2013年10月期间在我院初治的86例Ⅲ期NSCLC患者分为试验组与对照组各43例。试验组采用TP方案同步放化疗,对照组单纯放疗;两组患者放疗结束后继续序贯化疗;评价两组患者的近、远期疗效和不良反应。结果:整理分析后发现,试验组的有效率为81.40%,显著高于对照组58.14%,差异有统计学意义(P=0.019);试验组2年生存率51.16%,高于对照组27.91%,差异有统计学意义(P=0.027);不良反应骨髓毒性反应显著高于对照组,但经对症治疗后未出现不可逆重大并发症。结论:3DCRT联合TP方案同步放化疗治疗Ⅲ期非小细胞肺癌的近、远期临床疗效是显著的,毒副反应不影响治疗计划。Objective： To analyzed the clinical efficacy of 3DCRT combined with docetaxel/paclitaxel plus cisplatin（ TP） concurrent chemoradiotherapy for stage non- small cell lung cancer. Methods： In the study,a total of 86 cases with Ⅲ stage NSCLC in our in- patient department from January 2010 to October 2013 were analysed. These patients were divided into experimental group and control group,43 cases in each. The experimental group received3 DCRT combined with docetaxel / paclitaxel plus cisplatin（ TP） concurrent chemoradiotherapy,while the control group was only acceppted by 3DCRT. Following with chemotherapy. After that,all the data,including responses,survival rate and toxicity were collected and analysed. Results： After analysis of these data,the respones rate of the experimental group was significantly higher than that of control group（ 81. 40% vs 58. 14%,P = 0. 019）. The 2 year- survival tate of the experimental group was significantly higher than that of control group（ 51. 16% vs 27. 91%,P = 0. 027）. Bone marrow toxicity reaction is significantly higher than the control group,but not present irreversible major complications after symptomatic treatment. Conclusion： The shot- and long- term clinical curative effect of chemoradiation for Ⅲstage NSCLC patients is remarkable,toxic and adverse reaction does not affect the treatment plan.

关 键 词：三维适形放疗 同步放化疗 Ⅲ期非小细胞肺癌 疗效 

分 类 号：R734.2[医药卫生—肿瘤]