外泌体与白血病  

Exosomes and leukemia

作　　者：任秀敏[1] 贾秀红[1] Ren Xiumin Jia Xiuhong(Department of Pediatrics, the Affiliated Hospital of Binzhou Medical University ,Binzhou 256603, Chin)

机构地区：[1]滨州医学院附属医院儿科,256603

出　　处：《国际儿科学杂志》2017年第1期36-39,共4页International Journal of Pediatrics

基　　金：山东省自然科学基金（ZR2014HL032）;山东省医药卫生科技发展项目（2014WS0183）

摘　　要：外泌体是一种含有生物活性成分及信号分子的细胞外纳米级囊泡，能被体内细胞释放。白血病细胞来源的外泌体存在于白血病患者的血浆及白血病细胞培养上清液中，能把内部含有的白血病相关抗原及各种微小RNA呈递给靶细胞，不仅影响白血病的发生发展，也与白血病的治疗及预后密切相关。Exosome is a type of nanosized membrane microvesicle that contains bioactive constituents and signal molecules. Exosomes have been shown to be released by the cells in vivo. Leukemia cell-derived exosomes were found in the plasma of leukemia patients and supernatant of leukemia cells after centrifuge. Leukemia cell-derived exosomes and Technology Development Program of Medicine can transfer leukemia-associated anti- gens and microRNA to target cells. Not only does it affect the development of leukemia, but it is also closely re- lated to the treatment and prognosis of leukemia.

关 键 词：外泌体 白血病 

分 类 号：R733.7[医药卫生—肿瘤]