神经前体细胞表达下调蛋白9在胰腺癌组织中的表达及临床意义  

Expression of NEDD9 and its clinical significance in pancreatic cancer

作　　者：吴铁龙[1] 薛丽莉[1] 戴圆圆[1] 盛颖玥[1] 王文远[1] 薛育政[1] WU Tielong XUE Lili DAI Yuanyuan et al(Department of Gastroenterology, The Third People＇s Hospital of Wuxi, Wuxi, Jiangsu 214000, China)

机构地区：[1]无锡市第三人民医院消化科,江苏无锡214000

出　　处：《临床肝胆病杂志》2017年第1期130-132,共3页Journal of Clinical Hepatology

基　　金：江苏省"六大人才高峰"基金(WSN-066);江苏省"333工程"科研项目(CAE01101-06);无锡市医院管理中心科研项目(YGZXQ1310);无锡市社会发展科技支撑项目(CSE31N1415)

摘　　要：目的检测神经前体细胞表达下调蛋白(NEDD)9在胰腺癌和癌旁组织的表达情况,分析其与胰腺癌进展、预后的关系。方法收集2005年8月-2010年12月于无锡市第三人民医院治疗的98例胰腺癌患者的癌和癌旁组织样本,应用免疫组化技术检测患者胰腺癌和癌旁组织中NEDD9的表达,并对NEDD9表达与胰腺癌临床病理特征的关系进行分析。计数资料组间比较采用χ2检验。结果胰腺癌组织中NEDD9的高表达率明显高于癌旁组织(57.1%vs 41.8%,χ2=4.592,P=0.032)。胰腺癌组织NEDD9的表达与患者TNM分期、分化程度及有无淋巴结转移相关(χ2值分别为45.02、20.41、36.21,P值均<0.001);与性别、年龄、肿瘤部位、有无肝转移无相关性(P值均>0.05)。结论 NEDD9可能在胰腺癌的发展和侵袭转移中起着一定的作用,有可能作为评估胰腺癌预后的分子指标和治疗靶点。Objective To investigate the expression of neural precursor cell -expressed,developmentally down -regulated 9 （NEDD9）in pancreatic cancer tissues and adjacent tissues and its association with the progression and prognosis of pancreatic cancer.Methods A total of 98 patients with pancreatic cancer who were treated in The Third People′s Hospital of Wuxi from August 2005 to December 2010 were en-rolled,and the samples of pancreatic cancer tissues and adjacent tissues were collected.Immunohistochemistry was used to measure the ex-pression of NEDD9 in pancreatic cancer tissues and adjacent tissues.The chi -square test was used for comparison of categorical data be-tween groups.Results The high expression rate of NEDD9 in pancreatic cancer tissues was significantly higher than that in adjacent tissues （57.1% vs 41.8%,χ2 =4.592,P =0.032）.The expression of NEDD9 in pancreatic cancer tissues was significantly associated with TNM stage,degree of tumor differentiation,and lymph node metastasis （χ2 =45.02,20.41,and 36.21,all P 〈0.001）and not associated with sex,age,tumor location,or presence or absence of liver metastasis （all P 〉0.05）.Conclusion NEDD9 may play a role in the progres-sion and invasion /metastasis of pancreatic cancer and can be used as a prognostic marker and a therapeutic target for pancreatic cancer.

关 键 词：胰腺肿瘤 神经前体细胞表达下调蛋白 9 病理状态 体征和症状 

分 类 号：R735.9[医药卫生—肿瘤]