肿瘤坏死因子α诱导蛋白8样分子2在肝脏及胃肠道肿瘤发生发展中的作用  

Role of tumor necrosis factor- alpha- induced protein 8-like 2 in development and progression of liver and gastrointestinal tumors

作　　者：孔丽[1] 金萌[2] 赵素贤[1] KONG Li JIN Meng ZHAO Suxian(Department of Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China)

机构地区：[1]河北医科大学第三医院肝病科,石家庄050051 [2]河北医科大学第三医院中医外科,石家庄050051

出　　处：《临床肝胆病杂志》2017年第1期175-179,共5页Journal of Clinical Hepatology

基　　金：河北省科技厅课题(2015043467);河北省卫生厅课题(ZL20140032)

摘　　要：肝脏及胃肠道肿瘤是严重影响人类健康的恶性疾病,治疗效果及预后差。肿瘤坏死因子α诱导蛋白8样分子2(TIPE2)可负性调控固有免疫和适应性免疫,具有维持免疫稳态的作用。近年来发现TIPE2可通过影响多条信号通路,在肿瘤的发生发展中发挥抑制作用。简述了TIPE2的结构及功能,介绍了TIPE2对Ras、Ral、Rac等肿瘤相关信号通路及其下游分子的调控作用,并对TIPE2在肝脏及胃肠道肿瘤中的作用及相关信号通路、研究进展进行了总结。Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis.Tumor necrosis factor -alpha -induced protein 8 -like 2 （TIPE2）can negatively regulate innate immunity and adaptive immunity and maintain immune ho-meostasis.Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors.This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor -related sig-naling pathways such as Ras,Ral,and Rac and downstream molecules,as well as the role of TIPE2 in liver and gastrointestinal tumors,re-lated signaling pathways,and research advances.

关 键 词：肝肿瘤 胃肿瘤 肠肿瘤 肿瘤坏死因子 α诱导蛋白 8 样分子 2 综述 

分 类 号：R735[医药卫生—肿瘤]