血清抵抗素、ox-LDL及hsCRP水平与急性缺血性脑血管疾病严重程度的相关性  

Correlation among serum levels of resistin,ox-LDL,hsCRP and severity of acute ischemic cerebrovascular diseases

作　　者：闫佳兰[1] 李波[1] 高利涛[1] 徐玉[1] 王丽[1] 王雪笠[1] YAN Jia-lan LI Bo GAO Li-tao XU Yu WANG Li WANG Xue-li(Department of Neurology, Be- thune International Peace Hospital of Chinese PLA, Shijiazhuang, Hebei, 050082, Chin)

机构地区：[1]中国人民解放军白求恩国际和平医院神经内科,河北石家庄050082

出　　处：《心血管康复医学杂志》2017年第1期45-48,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨血清抵抗素、氧化型低密度脂蛋白(ox-LDL)及高敏C反应蛋白(hsCRP)水平与急性缺血性脑血管疾病严重程度的相关性。方法:选择于2013年11月~2014年11月就诊于我院的急性缺血性脑血管疾病患者92例,包括短暂性脑缺血发作(TIA)患者36例(TIA组),可逆性缺血性脑损害(RIBD)患者29例(RIBD组)和局限性脑梗塞(FCI)患者27例(FCI组),另选择健康志愿者70例作为正常对照组。检测比较各组血清抵抗素、ox-LDL和hsCRP水平。Pearson相关分析血清抵抗素、ox-LDL和hsCRP水平与急性缺血性脑血管疾病严重程度的相关性。结果:与正常对照组比较,TIA组,RIBD组和FCI组的血清抵抗素[(0.26±0.42)μg/L比(0.63±0.38)μg/L比(0.91±0.45)μg/L、(0.89±0.42)μg/L]、ox-LDL[(334.3±142.5)mg/L比(451.7±15.8)mg/L比(518.3±205.7)mg/L、(520.7±198.9)mg/L]和hsCRP[(5.8±4.9)mg/L比(8.7±7.6)mg/L比(13.5±9.1)mg/L、(13.6±7.4)mg/L]水平均显著升高,(P均<0.01),且RIBD组和FCI组显著高于TIA组(P均<0.01),RIBD组和FCI组间无显著差异(P均>0.05)。Pearson相关分析表明,血清抵抗素、oxLDL和hsCRP水平与急性缺血性脑血管疾病严重程度呈显著正相关(r=0.473~0.902,P均<0.01)。结论:血清抵抗素、ox-LDL及hsCRP水平能够反映急性缺血性脑血管疾病病情严重程度,值得推广。Objective： To explore the correlation among serum levels of resistin, oxidized low density lipoprotein （oxLDL）, high sensitive C reactive protein （hsCRP） and severity of acute ischemic cerebrovascular diseases. Methods： A total of 92 patients with acute ischemic cerebrovascular diseases, who were treated in our hospital from Nov 2013 to Nov 2014, were seIected, including 36 cases with transient ischemic attack （TIA, TIA group）, 29 cases with reversible ischemic brain damage （RIBD, RIBD group） and 27 cases with focal cerebral infarction （FCI, FCI group）. Another 70 healthy volunteers were regarded as normal control group. Serum levels of resistin, ox-LDL and hsCRP were measured and compared among all groups. Pearson correlation analysis was used to analyze the correlation among serum levels of resistin, ox-LDL, hsCRP and severity of acute ischemic cerebrovascular diseases. Results： Compared with normal control group, there were significant rise in serum levels of resistin [ （0.26±0. 42） μg/L vs. （0.63 ± 0.38） μg/L vs. （0.91 ± 0.45） μg/L, （0.89 ±0.42） μg/L], ox-LDL [ （334. 3 ± 142.5） mg/L vs. （451.7± 15.8） mg/Lvs. （518.3±205.7） mg/L, （520.7±198.9） mg/L] andhsCRP [ （5.8±4.9） mg/Lvs. （8.7±7.6） mg/L vs. （13.5±9. 1） mg/L, （13.6± 7. 4） mg/L] in TIA group, RIBD group and FCI group （P〈0.01 all） ; those of RIBD group and FCI group were higher than that of TIA group （P〈0. 01 all）, and there were no signifi- cant difference in above indexes between RIBD group and FCI group （P〉0.05 all）. Pearson correlation analysis indicated that serum levels of resistin, ox-LDL and hsCRP were significant positively correlated with severity of acute ischemic cerebovascular disease （r = 0. 47340. 902, P〈0. 01 all）. Conclusion： Serum levels of resistin, ox-LDL and hsCRP can reflect severitv of acute ischemic cerebrovascular diseases, which is worth extending.

关 键 词：抵抗素 脂蛋白类 LDL C反应蛋白质 脑血管障碍 

分 类 号：R743.31[医药卫生—神经病学与精神病学]