RNA-Seq技术在白念珠菌致病机理研究中的应用  

RNA-Seq for pathogenesis of Candida albicans

作　　者：刘建钗[1,2,3] 柳焕章[2] 刘彦威[2,3] 闫金坤[2,3] 张鹤平[2] 苏敬良[1] 

机构地区：[1]中国农业大学动物医学院预防兽医系,北京100094 [2]河北工程大学农学院动物医学系,邯郸056021 [3]河北省禽病工程技术研究中心,邯郸056021

出　　处：《中国人兽共患病学报》2017年第1期72-80,共9页Chinese Journal of Zoonoses

基　　金：河北省科技支撑项目(No.16226311D)~~

摘　　要：本文介绍了白念珠菌及其所致疾病的特点,阐述了白念珠菌致病机制的复杂性和转录组测序(RNA-Seq)技术的优势,回顾了RNA-Seq技术在白念珠菌致病机理研究中的应用情况,分析了以往研究中存在的不足,展望了此类研究未来的可能发展趋势。总之,RNA-Seq技术的不断改进并用于白念珠菌致病机理的深入研究将会带来令人瞩目的成就。In the paper, we introduced the peculiarity of Candida albicans and the disease caused by it, expounded the complexity of the pathogenesis, enumerated the advantages of the RNA Seq and reviewed its application to study on the patho- genesis of Candida albicans, found out some shortages in previous studies, and anticipated the possible trends of such study in future. In conclusion, some remarkable achievements will bring about by use of improved RNA-Seq for intensive researches on the pathogenesis of Candida albicans.

关 键 词：白念珠菌 致病机理 RNA-SEQ 

分 类 号：R379.4[医药卫生—病原生物学]