血清结合珠蛋白在宫颈癌诊断中的应用研究  

Application of Haptoglobin in Cervical Cancer Diagnosis

作　　者：王冰[1] 朱月蓉[1] 何玉杰[1] 邱红[1] 

机构地区：[1]解放军第81医院检验科,南京210002

出　　处：《现代检验医学杂志》2017年第1期106-108,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨血清结合珠蛋白(haptoglobin,Hp)的含量在宫颈癌诊断中的临床意义。方法收集45例宫颈癌患者、37例宫颈良性疾病患者和41例女性健康对照血清,采用免疫比浊法测定血清中Hp的含量,化学发光法测定SCC和CA125的含量,各组间比较采用t检验。结果宫颈癌患者Hp平均含量为1.69 g/L,与宫颈良性疾病患者Hp含量(0.90 g/L)和健康人血清Hp含量(0.69 g/L)相比差异均有统计学显著性意义(t值分别为3.26和4.42,P值分别为0.001和0.000)。在宫颈癌早期血清Hp含量即明显升高。Hp,SCC和CA125诊断宫颈癌的ROC曲线下面积分别为0.853,0.751和0.494。Hp,SCC和CA125诊断宫颈癌的灵敏度分别为87%,49%和29%,特异度分别为68%,88%和83%,三者联合检测的灵敏度为93%。结论血清结合珠蛋白在宫颈癌诊断中具有一定的临床价值,是潜在的血清肿瘤标志物。Objective To investigate the clinical value of serum Haptoglobin （Hp） levels in cervical cancer patients. Methods Serum H p （ with immunoturbidimetry method）, SCC, CA125 （with electrochemiluminescence immunoassay method） level were detected in 45 patients with cervical cancer,37patients with cervical benign disease and 41 female healthy controls. Re- suits Serum Hp level of cervical cancer patients （mean： 1.69 g/L） was strongly higher than the level of cervical benign dis- ease patients （mean：0.90g/L） and healthy subjects （mean：0.69 g/L） （t=3.26, 4.42,P=0.001,0.000,respectively）.Hp level rises highly in the early stage of cervical cancer. The area under receiver operating characteristic curve （AUCROC） of Hp was 0.853 which was higher than SCC （AUC=0.751） and CA125 （AUC= 0. 494）. The sensitivity of Hp,SCC,and CA125 were 87%,49% and 29% respectively. The specificity of Hp,SCC and CA125 were 68%,88%and 83% respective ly. Three tumor markers combined together could produce a positive detection rate of 93%. Conclusion The detection of Hp has clinic signit＇icance on diagnosis of cervical cancer,and it＇s possible to become a serum tumor marker.

关 键 词：结合珠蛋白 宫颈癌 肿瘤标志物 

分 类 号：R737.33[医药卫生—肿瘤] R730.43[医药卫生—临床医学]