咽部及鼻部非霍奇金淋巴瘤EBV感染与分型的相关性研究  

Correlation between EBV infections and classification of non-Hodgkin lymphoma of pharyngeal and nasal cavity

作　　者：芦二永[1] 张超[1] 王军旗[1] 苏吉利[1] 王月辉[1] 

机构地区：[1]河南科技大学临床医学院河南科技大学第一附属医院耳鼻咽喉科,河南洛阳471003

出　　处：《中华医院感染学杂志》2017年第3期639-641,共3页Chinese Journal of Nosocomiology

基　　金：河南省医学科技攻关计划指导性计划项目(201504020)

摘　　要：目的探讨咽部及鼻部非霍奇金淋巴瘤(NHL)EB病毒(EBV)感染与分型的相关性,为NHL的临床诊治提供参考。方法选取2015年3月-2016年3月诊治127例咽部及鼻部NHL患者NHL病变组织标本,进行免疫组化染色SP法及EBVR-1的原位杂交检测,分析结果。结果 86例为NK/T细胞淋巴瘤、31例为B细胞淋巴瘤、10例为T细胞淋巴瘤,构成比分别为67.72%、24.41%、7.87%,鼻腔及咽部NHL患者以NK/T细胞淋巴瘤为主,分别占81.58%、66.67%,扁桃体NHL患者以B细胞淋巴瘤为主,占62.50%,以上各病变部位的以NK/T细胞淋巴瘤与B细胞淋巴瘤分型之间比较差异均有统计学意义(P<0.05);NK/T细胞淋巴瘤患者85例EBVR-1阳性,B细胞淋巴瘤患者14例EBVR-1阳性,T细胞淋巴瘤患者7例EBVR-1阳性,阳性率分别为98.84%、45.16%、70.00%,不同淋巴瘤分型的EBVR-1阳性率比较差异有统计学意义(P<0.05)。结论咽部和鼻部NHL分型以NK/T细胞淋巴瘤多见,但扁桃体部位则以B细胞淋巴瘤多见,EBV感染在NK/T细胞淋巴瘤发生及发展中可能起到极为重要作用。OBJECTIVE To investigate the correlation between epstein-barr virus（EBV）infections and classification in non-hodgkin lymphoma（NHL）of pharyngeal and nasal cavity,so as to provide references for clinical diagnosis and treatment of NHL.METHODS Lesion tissue specimens of 127 cases of patients with pharyngeal and nasal cavity NHL from Mar.2015 to Mar.2016 were selected.Immunohistochemical staining SP method and in situ hybridization of EBVR-1were carried out,and the results were analyzed.RESULTS There were 86 cases of NK/T cell lymphoma,31 cases of B cell lymphoma,and 10 cases of T cell lymphoma,accounting for 67.72%,24.41%,and 7.87%,respectively.Nasal cavity and pharyngeal NHL patients were mainly NK/T cell lymphoma,accounting for 81.58% and 66.67%.Amygdala NHL patients were mainly B cell lymphoma,was accounting for62.50%.There were significant differences in NK/T-cell lymphoma and B-cell lymphoma classification between the above lesions（P〈0.05）.Totally 85 cases were EBVR-1positive of NK/T cell lymphoma,14 cases were EBVR-1positive of B cell lymphoma,and 7cases were EBVR-1positive of T cell lymphoma,with the positive rates of 98.84%,45.16% and 70.00%.The positive rates of EBVR-1in different lymphoma classification was significant（P〈0.05）.CONCLUSION NK/T cell lymphoma is common in pharyngeal and nasal cavity NHL classification,but B cell lymphoma is common in amygdala NHL classification,and EBV infection may play an important role in the pathogenesis and development of NK/T cell lymphoma.

关 键 词：非霍奇金淋巴瘤 EB病毒 咽部 鼻部 分型 

分 类 号：R739.63[医药卫生—肿瘤]