喹硫平与氯氮平联合治疗偏执性精神障碍的效果观察  

Observation on Effect of Quetiapine Combined With Clozapine in Treatment of Paranoid Mental Disorder

作　　者：郭艳红 金明华 朴俊香 

机构地区：[1]哈尔滨市朝鲜民族医医院精神科,黑龙江哈尔滨150076

出　　处：《中国继续医学教育》2017年第2期175-176,共2页China Continuing Medical Education

摘　　要：目的观察喹硫平与氯氮平联合治疗偏执性精神障碍的效果。方法将2015年5月-2016年5月本院收治偏执性精神障碍患者37例作为研究对象,按就诊日期单双号差异分组。18例单号就诊患者,进入对照组,治疗应用氯氮平。19例双号就诊患者,进入研究组,治疗应用喹硫平与氯氮平。治疗后对比两组的治疗总有效率。结果对照组无效4例,有效8例,显效6例,治疗总有效率77.78%。研究组无效1例,有效7例,显效11例,治疗总有效率94.74%。两组中研究组的治疗总有效率较高,差异有统计学意义(P<0.05)。结论偏执性精神障碍采用喹硫平与氯氮平治疗效果可靠,临床有效率高。Objective Observation on effect of quetiapine combined with clozapine treatment for paranoid mental disorder. Methods 37 patients of paranoid mental disorder who were treated in hospital from May 2015 to May 2016 to study and separated them into two groups according to their hospital-visitation date number（odd number or even number）; 18 patients of odd hospital-visitation date number were divided into control group were given with clozapine treatment, while another 19 patients of even hospitalvisitation date number divided into study group were given with quetiapine combined with clozapine treatment, and then compare patients＇ treatment effects between two groups. Results In the control group, 4 cases were ineffective, 8 cases were effective and 6 cases were markedly effective, the total effective rate was 77.78%. While, in the study group, 1 case was ineffective, 7 cases were effective and 11 cases were markedly effective, and the total effective rate was 94.74%. The total effective rate of treatment in study was higher than that in the control group, there was differential statistically significant（P〈0.05）. Conclusion Quetiapine combined with clozapine treatment is quite clinically effective for patients with paranoid mental disorder.

关 键 词：偏执性精神障碍 喹硫平 氯氮平 治疗 效果 

分 类 号：R74[医药卫生—神经病学与精神病学]