氮气等离子体注入改性对聚醚醚酮生物活性的影响  

Influence of nitrogen plasma immersion implantation on the biological activity of PEEK implant materials

作　　者：刘秀菊[1] 甘抗 刘红[1] 宋效庆[1] 牛德利[1] 陈天杰[1] 

机构地区：[1]吉林大学口腔医学院综合治疗科.吉林省牙发育及颌骨重塑与再生重点实验室,长春130021 [2]郑州大学第一附属医院口腔医学中心

出　　处：《现代口腔医学杂志》2017年第1期6-10,共5页Journal of Modern Stomatology

基　　金：吉林省产业技术研究与开发项目资助课题(2015Y038-3);吉林省产业技术研究与开发项目资助课题(JF2012C009-2);吉林大学研究生创新基金资助项目(2016214);吉林省科技厅自然科学基金资助课题(201215051)

摘　　要：目的探讨氮气等离子体注入(PⅢ)改性聚醚醚酮(PEEK)植入材料对其生物学活性的影响。方法利用等离子注入技术制备氮气PⅢ改性PEEK材料,SEM观察改性材料的表面形貌;MG-63成骨细胞与PEEK试件共培养测定PⅢ改性材料对MG-63成骨细胞的粘附、增殖的影响;SEM观察改性材料表面粘附的MG-63成骨细胞的形态。结果氮气注入PEEK改性材料的表面可见均匀分布、散在的纳米级颗粒状物质;细胞培养实验显示,氮气PⅢ改性组的细胞数量明显高于PEEK组;MG-63成骨细胞在改性材料表面的伸展性良好。结论氮气PⅢ改性促进了MG-63成骨细胞的粘附、增值,可显著提高PEEK植入材料的生物活性。Objective We aimed to investigate the influence of nitrogen plasma immersion implantation（PⅢ）on the biological activity of polyetheretherketone（PEEK） and provide theoretical basis for clinical application of PEEK implant materials. Methods Nitrogen PⅢ-modified PEEK material was prepared by plasma injection technology.The microstructure of specimens was observed by scanning electron microscopy（SEM）. The effects of PⅢ-modified materials on adhesion and proliferation of MG-63 Cells were determined by co-culturing MG-63 Cells and PEEK specimens. The morphological characteristics of MG-63 Cells that adhered to the surface of materials were observed by SEM. Results Nanometer granular structure was distributed uniformly on the surface of modified material. Cell experiments demonstrated that the number of cells of PⅢ-modified group was significantly higher than that of PEEK group（P0.05）. MG-63 Cells had good extensibility on the surface of the modified materials. Conclusion Nitrogen PⅢ modification can significantly increase the biological activity of PEEK implant materials.

关 键 词：聚醚醚酮 等离子体浸没注入 生物活性 

分 类 号：R783.1[医药卫生—口腔医学]