4种甲氧基丙烯酸酯类杀菌剂不同剂型对斑马鱼急性毒性效应  

Acute Toxicity of Different Formulation of Four Strobilurin Fungicides to the Zebrafish (Brachydonio rerio)

作　　者：贾伟[1] 蒋红云[1] 张兰[1] 张燕宁[1] 毛连刚[1] Jia Wei Jiang Hongyun Zhang Lan Zhang Yanning Mao Liangang(Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China)

机构地区：[1]中国农业科学院植物保护研究所,北京100193

出　　处：《生态毒理学报》2016年第6期242-251,共10页Asian Journal of Ecotoxicology

基　　金：国家自然科学基金(31272079;31171967)

摘　　要：采用半静态法测定了4种甲氧基丙烯酸酯类杀菌剂原药及制剂对斑马鱼(Brachydonio rerio)急性毒性。结果表明,以实测浓度计,250 g·L^(-1)嘧菌酯悬浮剂对斑马鱼的96 h半数致死浓度(LC50)值为0.539 mg·L^(-1),急性毒性为高毒,95%嘧菌酯原药和50%嘧菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为1.09和1.21 mg·L^(-1),急性毒性均为中毒;98%啶氧菌酯原药和22.5%的啶氧菌酯悬浮剂对斑马鱼的LC50(96 h)值分别为0.0974和0.0972 mg·L^(-1),急性毒性均为剧毒;95%吡唑醚菌酯原药、15%吡唑醚菌酯悬浮剂和250 g·L^(-1)吡唑醚菌酯乳油对斑马鱼的LC50(96 h)值为0.0613、0.0549和0.0487 mg·L^(-1),急性毒性均为剧毒;95%醚菌酯原药和50%醚菌酯水分散粒剂对斑马鱼的LC50(96 h)值分别为0.468和0.702 mg·L^(-1),急性毒性均为高毒。这4种甲氧基丙烯酸酯类杀菌剂对斑马鱼均有较高风险,会对其他水生生物也存在潜在的风险。Acute toxicity of different formulation of four strobilurin fungicides to zebrafish（ Brachydonio rerio） was detected with the semi-static method. Based on measured concentrations,results showed that 250 g·L^-1azoxystrobin suspension concentrate（ SC） is very toxic to zebrafish with an LC50（ 96 h） value of 0.539 mg·L^-1. In contrast,95% azoxystrobin technical material（ TC） and 50% azoxystrobin water dispersible granule（ WG） were moderately toxic to zebrafish with LC50（ 96 h） values of 1.09 and 1.21 mg·L^-1,respectively. Both 98% picoxystrobin TC and22.5% picoxystrobin SC were extremely toxic to zebrafish with LC50（ 96 h） values of 0.0974 and 0.0972 mg·L^-1.All test fungicides pyraclostrobin were also extremely toxic to zebrafish with the relative toxicity（ LC50） in decreasing order as follows： 95% pyraclostrobin TC（ 0.0613 mg·L^-1） 15% pyraclostrobin SC（ 0.0549 mg·L^-1） 250 g·L^-1pyraclostrobin emulsifiable concentrates（ EC）（ 0. 0487 mg·L^-1）. 95% kresoxim-methyl TC and 50%kresoxim-methyl WG were very toxic to zebrafish,and their LC50（ 96 h） values were 0.468 and 0.702 mg·L^-1,respectively. These results suggested that all tested strobilurin fungicides have the potential risk to zebrafish and the other aquatic organisms.

关 键 词：甲氧基丙烯酸酯类杀菌剂 斑马鱼 急性毒性 剂型 中毒症状 

分 类 号：X171.5[环境科学与工程—环境科学]