Catalytic Thiourea Promoted Electrophilic Thiocyanation of Indoles and Aromatic Amines with NCS/NH4SCN  

作　　者：Cancan Wang Zhonghao Wang Liang Wang Qun Chen Mingyang He 

机构地区：[1]School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China

出　　处：《Chinese Journal of Chemistry》2016年第11期1081-1085,共5页中国化学（英文版）

基　　金：This project was financially supported by the National Natural Science Foundation of China （No. 21302014）.

摘　　要：A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosueeinimide （NCS） was found to be indispensable, and thiourea could greatly promote the reaction.A simple and efficient protocol for the electrophilic thiocyanation of indoles and aromatic amines with thiourea/NCS/NH4SCN system has been developed. The major features of the present procedure are the mild conditions, good yields, short reaction times, and the use of inexpensive and readily available organocatalyst. Moreover, N-chlorosueeinimide （NCS） was found to be indispensable, and thiourea could greatly promote the reaction.

关 键 词：THIOCYANATION INDOLES aromatic amines catalytic thiourea N-chlorosuccinimide 

分 类 号：O625.631[理学—有机化学] TP332[理学—化学]