supported by the Natural Science Foundation of Jilin Province(20210101134JC);the National Natural Science Foundation of China(22171042,21831002,22193012);the Fundamental Research Funds for the Central Universities.
Alicyclic nitrogen heterocycles,such as enantioenriched polycyclic fused[1,2-a]indoline derivatives,are widespread in natural products,agrochemicals and pharmaceutical agents.Existing methods predominantly rely on the...
supported by the National Natural Science foundation of China(Nos.22225104,92356302,22071077,21975102).
Indole derivatives,especially bisindolylesters,have attracted intense attention due to their important applications in medicinal chemistry and organic synthesis.Here we develop a Lewis acid-catalyzed efficient and reg...
Support by the National Natural Science Foundation of China(Nos.22271244 and 22071211);the Hunan Provincial Natural Science Foundation of China(Nos.2023JJ40561 and 2022JJ40359);the Hunan Provincial Health Commission Foundation(B202313020111);Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2022C02)is gratefully acknowledged.
The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analoguesthrough three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage of indoles.Thi...
supported by the National Key Research and Development Program of China (2022YFB4101800);the National Natural Science Foundation of China (22231002);the Guangdong Basic and Applied Basic Research Foundation (2024B1515040027)。
Indole is a promising heteroarene in many natural products and pharmaceuticals;therefore, various synthetic methods for indole functionalizations have arisen in recent years. Herein, we report a Pd-catalyzed deoxygena...
support from the National Natural Science Foundation of China(Grant Nos.22378106,21878072,21706058,and 22002169);the Natural Science Foundation of Hunan Province(Grant No.2020JJ2011);the China Postdoctoral Science Foundation(No.2019M662774).
Comprehensive Summary The activation of inert chemical bonds is an exciting area of research in chemistry because it enables the direct utilization of readily available starting materials and promotes atom-and step-ec...
S.P.received funding from the Hans-Bockler-Stiftung.T.Y.W.C.received funding from the German Academic Exchange Service(DAAD).
Multiple Sclerosis(MS)is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system.T cells play an intriguing role in ...
supported by the National Natural Science Foundation of China(No.22208302);the Natural Science Foundation of Zhejiang Province of China(Nos.LQ21B020006,ZJ2022039)。
A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green manners.Moreover,a contr...
We thank financial support from NSFC(22061006);Guizhou Provincial Program(GCC[2023]047,GCC[2023]078,ZK[2023]043,ZK[2022]144,ZK[2022]480).
The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric catalysis.Herein,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that...
Indole and its derivatives represent the most important heterocycles that are widely present in bioactive molecules,natural products and advanced materials,and thus functionalization of simple indoles to construct com...
the National Natural Science Foundation of China(Nos.22371007,22071005);the Peking University Medicine Fund for world's leading discipline or discipline clusterdevelopment(BMU2022DJXK002).
A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into ...