INDOLES

作品数:107被引量:99H指数:6
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相关领域:理学更多>>
相关作者:马建峰徐善生王佰全李滨谢维佳更多>>
相关机构:南开大学中国科学院郑州大学武汉大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Enantioselective copper-catalyzed dearomative borylative cyclization of indoles and mechanistic insights
《Science China Chemistry》2025年第2期670-678,共9页Yanfei Li Xuetao Li Zheng Zhang Yiliang Zhang Xiuping Yuan Jianjun Yin Simin Wang Wei Guan Qian Zhang Tao Xiong 
supported by the Natural Science Foundation of Jilin Province(20210101134JC);the National Natural Science Foundation of China(22171042,21831002,22193012);the Fundamental Research Funds for the Central Universities.
Alicyclic nitrogen heterocycles,such as enantioenriched polycyclic fused[1,2-a]indoline derivatives,are widespread in natural products,agrochemicals and pharmaceutical agents.Existing methods predominantly rely on the...
关键词:copper catalysis DEAROMATIZATION borylative cyclization INDOLES DFT calculations 
Lewis Acid-catalyzed Regioselective Addition of Allenoates to Indoles for Synthesis of Bisindolylesters
《Chemical Research in Chinese Universities》2025年第1期48-58,共11页XIE Fuyu HE Jianghua ZHANG Yuetao 
supported by the National Natural Science foundation of China(Nos.22225104,92356302,22071077,21975102).
Indole derivatives,especially bisindolylesters,have attracted intense attention due to their important applications in medicinal chemistry and organic synthesis.Here we develop a Lewis acid-catalyzed efficient and reg...
关键词:B(C_(6)F_(5))_(3) Al(C_(6)F_(5))_(3) INDOLE ALLENOATE Indolylester 
Pictet-spengler/transamination cascade reaction of indoles for modular synthesis of marinoquinoline analogues
《Green Synthesis and Catalysis》2024年第4期310-314,共5页Jinjin Chen Pingyu Jiang Xinping Liu Huawen Huang Guojiang Mao Guo-Jun Deng 
Support by the National Natural Science Foundation of China(Nos.22271244 and 22071211);the Hunan Provincial Natural Science Foundation of China(Nos.2023JJ40561 and 2022JJ40359);the Hunan Provincial Health Commission Foundation(B202313020111);Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2022C02)is gratefully acknowledged.
The Pictet-Spengler/transamination cascade reaction enables modular synthesis of marinoquinoline analoguesthrough three-component indole ring-expansion/cyclization in the manner of novel N1–C2 cleavage of indoles.Thi...
关键词:Pictet-spengler reaction Indole ring-expansion N1-C2 cleavage INDOLE Marinoquinoline analogues 
Palladium-catalyzed vinylation of indoles with vinyl ethers via deoxygenative coupling
《Science China Chemistry》2024年第11期3785-3790,共6页Bowen Wang Jianxiao Li Wanqing Wu Liangbin Huang Huanfeng Jiang 
supported by the National Key Research and Development Program of China (2022YFB4101800);the National Natural Science Foundation of China (22231002);the Guangdong Basic and Applied Basic Research Foundation (2024B1515040027)。
Indole is a promising heteroarene in many natural products and pharmaceuticals;therefore, various synthetic methods for indole functionalizations have arisen in recent years. Herein, we report a Pd-catalyzed deoxygena...
关键词:INDOLE VINYLATION regioselectivity N-vinyl indole palladium catalyst 
Copper-Mediated Selective Multiple Inert Chemical Bonds Cleavage for Cyanation of Indoles via Tandem Carbon and Nitrogen Atom Transfer
《Chinese Journal of Chemistry》2024年第19期2299-2304,共6页Shimin Xie Fangfang Cai Lixin Liu Lebin Su Jianyu Dong Yongbo Zhou 
support from the National Natural Science Foundation of China(Grant Nos.22378106,21878072,21706058,and 22002169);the Natural Science Foundation of Hunan Province(Grant No.2020JJ2011);the China Postdoctoral Science Foundation(No.2019M662774).
Comprehensive Summary The activation of inert chemical bonds is an exciting area of research in chemistry because it enables the direct utilization of readily available starting materials and promotes atom-and step-ec...
关键词:Multiple inert chemical bonds Bond cleavage Carbon and nitrogen atom transfer Cleavage reactions Oxidation Copper Cyanation IndoleSelectivity 
How exercise shapes the anti-inflammatory environment in multiple sclerosis–a conceptual framework focusing on tryptophan-derived molecules in T cell differentiation
《Translational Exercise Biomedicine》2024年第3期305-319,共15页Tiffany Y.Wences Chirino Niklas Joisten Philipp Zimmer Sebastian Proschinger 
S.P.received funding from the Hans-Bockler-Stiftung.T.Y.W.C.received funding from the German Academic Exchange Service(DAAD).
Multiple Sclerosis(MS)is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system.T cells play an intriguing role in ...
关键词:aryl hydrocarbon receptor T cells multiple sclerosis INDOLES kynurenine pathway physical exercise 
Nitrite-catalyzed economic and sustainable bromocyclization of tryptamines/tryptophols to access hexahydropyrrolo[2,3-b]indoles/tetrahydrofuroindolines in batch and flow
《Chinese Chemical Letters》2024年第7期247-252,共6页Xiao Xiao Biao Chen Jia-Wei Li Jun-Bo Zheng Xu Wang Hang Zhao Fen-Er Chen 
supported by the National Natural Science Foundation of China(No.22208302);the Natural Science Foundation of Zhejiang Province of China(Nos.LQ21B020006,ZJ2022039)。
A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green manners.Moreover,a contr...
关键词:Tryptamines and tryptophols NITRITE Economic and sustainable bromocyclization HPI and TFI structures Bath and flow 
Chiral Phenol-2NO Ligand Cooperation with Achiral Organic Base in the Zn(II)-Catalyzed Asymmetric Alkylation Reaction of Indoles被引量:2
《Chinese Journal of Chemistry》2024年第13期1474-1480,共7页Ke-Lan Xu Yu-Heng Wang Xi-Rui Wang Pan Hu Bo-Wen Pan Wen-Jing Zhang Zi-Yue Chen Ying Zhou Xiong-Li Liu 
We thank financial support from NSFC(22061006);Guizhou Provincial Program(GCC[2023]047,GCC[2023]078,ZK[2023]043,ZK[2022]144,ZK[2022]480).
The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric catalysis.Herein,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that...
关键词:Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis ALKYLATION Synthesis design HETEROCYCLES 
Atroposelective Synthesis of 3-Aryl-Indoles Through a One-Pot 2,3-Difunctionalization of Simple Indoles
《CCS Chemistry》2024年第7期1672-1680,共9页Lei Dai Yu-Li Sun Jiami Guo Xueting Zhou Qingqin Huang Yixin Lu 
Indole and its derivatives represent the most important heterocycles that are widely present in bioactive molecules,natural products and advanced materials,and thus functionalization of simple indoles to construct com...
关键词:axial chirality atroposelectivity sequential catalysis difunctionalization of indoles chiral phosphoric acid 
C—F Bond Insertion into Indoles with CHBr_(2)F:An Efficient Method to Synthesize Fluorinated Quinolines and Quinolones
《Chinese Journal of Chemistry》2024年第10期1128-1132,共5页Chao Li Lei Chen Hongye Wang Zixi Yan Bin Lyu Weiping Lyu Changwei Jiang Dehua Lu Jiaxing Li Ning Jiao Song Song 
the National Natural Science Foundation of China(Nos.22371007,22071005);the Peking University Medicine Fund for world's leading discipline or discipline clusterdevelopment(BMU2022DJXK002).
A mild and practical method for synthesizing fluorinated quinoline derivatives,which have a wide range of applications in pharmaceuticals,materials,and organic synthesis,was described through C—F bond insertion into ...
关键词:Skeleton edit Fluorocarbene Ring expansion QUINOLINE QUINOLONE 
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