How exercise shapes the anti-inflammatory environment in multiple sclerosis–a conceptual framework focusing on tryptophan-derived molecules in T cell differentiation  

作　　者：Tiffany Y.Wences Chirino Niklas Joisten Philipp Zimmer Sebastian Proschinger 

机构地区：[1]Sports Medicine Research Group,Institute for Sport and Sport Science,TU Dortmund University,Dortmund,Germany [2]Division of Exercise and Movement Science,Institute for Sport Science,University of Göttingen,Göttingen,Germany

出　　处：《Translational Exercise Biomedicine》2024年第3期305-319,共15页运动转化生物医学(英文)

基　　金：S.P.received funding from the Hans-Bockler-Stiftung.T.Y.W.C.received funding from the German Academic Exchange Service(DAAD).

摘　　要：Multiple Sclerosis(MS)is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system.T cells play an intriguing role in MS immunopathology and research over the past decade has shown that tryptophan(TRP)-derived metabolites are crucial molecules affecting T cell differentiation,also in MS,and are modulated by exercise.The aryl hydrocarbon receptor(AHR),for which TRP metabolites are well-known ligands,has been elucidated as main driver of T cell differentiation and an enhanced anti-inflammatory cellular milieu in human MS and preclinical mouse models.By integrating evidence from different research fields,the aim of this article is to summarize and critically discuss the potential of exercise to activate the AHR in T cells by modulating circulating TRP-derived metabolites and to provide a conceptual framework on potential benefits in MS immunopathology.

关 键 词：aryl hydrocarbon receptor T cells multiple sclerosis INDOLES kynurenine pathway physical exercise 

分 类 号：O62[理学—有机化学]