Palladium/Copper Cocatalyzed Coupling Reaction of Aroyl Hydrazides with Indoles  

作　　者：Congrong Liu Fulai Yang 

机构地区：[1]School of Environment Engineering, Nanjing Institute of Technology, Jiangsu, Nanjing 211167, China [2]Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China

出　　处：《Chinese Journal of Chemistry》2016年第12期1213-1217,共5页中国化学（英文版）

摘　　要：An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1：1 mixture of dimethyl sulfoxide and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.An unprecedented palladium/copper cocatalyzed coupling reaction of indoles with simple aroyl hydrazides has been developed under aerobic conditions. A range of aroyl hydrazides underwent palladium/copper cocatalyzed oxidative arylation with indoles open to air in a 1：1 mixture of dimethyl sulfoxide and nitromethane to give structurally diverse 2-arylindoles or 3-arylindoles in moderate to good yields. The reaction well tolerates a wide variety of functional groups such as alkoxy, halo, ester.

关 键 词：aroyl hydrazides coupling reaction INDOLE palladium catalyst copper catalyst 

分 类 号：TQ225.24[化学工程—有机化工] TQ225.54