Antiviral and Antibacterial Activities of N-（4-Substituted phenyl） Acetamide Derivatives Bearing 1,3,4-Oxadiazole Moiety  

作　　者：Ling Chen Peiyi Wang Zhenxing Li Lei Zhou Zhibing Wu Baoan Song Song Yang 

机构地区：[1]State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, Guizhou 550025, China [2]College of Pharmacy, East China University of Science & Technology, Shanghai 550025, China

出　　处：《Chinese Journal of Chemistry》2016年第12期1236-1244,共9页中国化学（英文版）

摘　　要：In this paper, a series of N-（4-substituted phenyl） acetamide derivatives bearing 1,3,4-oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus （TMV） but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. cit- ri. Among the derivatives, TC8 and TC20 exerted the strongest curative activities against TMV, with half-maximal effective concentration （EC50） values of 239.5 and 236.2μg/mL, respectively, which were comparable to that of ningnanmycin （EC50=273.2μg/mL）. Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.In this paper, a series of N-（4-substituted phenyl） acetamide derivatives bearing 1,3,4-oxadiazole moiety were synthesised. Preliminary bioassays revealed that these compounds not only exhibited favourable antiviral activities toward tobacco mosaic virus （TMV） but also demonstrated sustained inhibition activities against plant pathogenic bacteria, including Xanthomonas oryzae pv. oryzae, Ralstonia solanacearum, and Xanthomonas axonopodis pv. cit- ri. Among the derivatives, TC8 and TC20 exerted the strongest curative activities against TMV, with half-maximal effective concentration （EC50） values of 239.5 and 236.2μg/mL, respectively, which were comparable to that of ningnanmycin （EC50=273.2μg/mL）. Given their simple synthesis, the target compounds can serve as alternative antiviral candidates.

关 键 词：1 3 4-OXADIAZOLE ACETAMIDE synthesis ANTIVIRAL ANTIBACTERIAL 

分 类 号：S859.796[农业科学—临床兽医学] TQ464.71[农业科学—兽医学]