经期对育龄期女性帕金森病患者的影响  

The Clinical Features of Women of Childbearing Age with Parkinson's Disease in Menstrual Cycles

作　　者：万志荣[1] 王凌霄[1] 苏东宁[2] 高婧[1] 冯涛[2] 

机构地区：[1]航天中心医院神经内科,北京100049 [2]首都医科大学附属北京天坛医院神经病学中心神经变性病科,北京100050

出　　处：《神经损伤与功能重建》2017年第1期44-47,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:调查育龄期女性帕金森病(PD)患者受经期影响的临床特征。方法:连续选取我院及天坛医院PD专病门诊就诊的发病时处于育龄期的女性PD患者,采用调查问卷,详细记录受经期影响的时间段及临床表现,同时收集发病年龄、病程、月经史、生育史、妇科疾病及手术史、UPDRS-Ⅲ评分、改良H-Y分级、贝克焦虑量表等资料。结果:共收集受经期影响女性PD患者88例,症状波动平均发生在经前3.5 d或月经后2.7 d,以经期中影响最常见;临床表现为药物起效慢,药效时间短。合并妇科疾病占60.2%,曾行妇科手术占43.2%,绝经年龄平均为(47.9±3.3)岁。患者非经期的UPDRS-Ⅲ评分、改良H-Y分级、贝克焦虑评分等方面均低于经期(P<0.01)。结论:女性育龄期PD患者易受经期影响,可发生在经期前中后不同时段,均表现为临床症状恶化。Objective： To analyze the clinical features of women of childbearing age with Parkinson＇ s disease （PD） in menstrual cycles. Methods： Women of childbearing age with PD from Aerospace Central Hospital and Beijing Tian Tan Hospital were collected. Time period and clinical manifestations in menstrual cycles, ages of onset, courses of disease, menstrual history, reproductive history, gynecological diseases and surgical history, UP- DRS- Ⅲ scores, modified H-Y stage and Beck Anxiety Inventory （BAI） were recorded and analyzed. Results： Eighty-eight cases are collected. The symptom fluctuations occur 3.5 days before menstruation or 2.7 days after menstruation, but mainly during menstruation with slowly drug action and short effect duration. 60.2% of the cases are combined with gynecological diseases, 43.2% have had gynecological operations. The average age of menopause is （47.9±3.3） years. There are significant statistical differences （P〈0.000） of UPDRS-Ⅲ scores, modified H-Y stages and BAI scores between menstrual period and non-menstrual period. Conclusion： Women of childbearing age with PD are susceptible to menstrual cycles. Deterioration of clinical symptoms occurs in different periods of menstruation.

关 键 词：帕金森病 育龄期 月经史 生育史 症状恶化 

分 类 号：R741[医药卫生—神经病学与精神病学] R743[医药卫生—临床医学]