基于低频振幅方法的强迫症患者静息态功能磁共振成像研究  

Resting-state functional magnetic resonance imaging of patients with obsessive-compulsive disorder based on amplitude of low-frequency fluctuation

作　　者：陶炯[2] 王相兰[3] 钟智勇[3] 韩自力[3] 韩洪瀛[3] 刘莎 张晋碚[3] 李凌江[1] 

机构地区：[1]中南大学湘雅二医院精神卫生研究所,长沙410011 [2]中山大学附属第三医院精神科 [3]中山大学附属第三医院精神科,广州510630 [4]广州惠爱医院放射科,广州510370

出　　处：《中华神经医学杂志》2017年第2期152-155,共4页Chinese Journal of Neuromedicine

摘　　要：目的探讨强迫症患者静息态功能磁共振成像（RS-fMRI）中低频振幅（ALFF）和低频振幅比率（fALFF）的改变及其意义。方法选择自2013年1月至2014年12月在中山大学附属第三医院精神科门诊的27例未经治疗的强迫症患者（强迫症组）和同期招募的29例年龄、性别、受教育年限相匹配的健康对照者（对照组），采用RS-fMRI技术扫描，比较2组受试者ALFF和fALFF的差异，并进一步分析其与临床症状严重程度之间的相关性。结果和对照组相比，强迫症组患者静息状态下右楔前叶ALFF明显降低，右楔前叶、左颞中回fALFF明显降低，差异均有统计学意义（P＜0．051；但没有发现ALFF与fALFF增高的脑区。右楔前叶ALFF、fALFF及左颞中回fALFF与耶鲁一布朗强迫量表总分无相关性（r=-0．130，P=0．518；r=-0．270，P=0．173；r=-0．041，P=-0．839）。结论静息状态下右楔前叶、左颞中回ALFF改变可能与强迫症的病理机制有关，但与强迫症状严重程度无关。Objective To analyze the altered amplitude of low-frequency fluctuation （ALFF） and fraction ALFF （fALFF） in patients with obsessive-compulsive disorder （OCD） using resting-state functional magnetic resonance imaging （RS-fMRI）. Methods Twenty-seven un-medicated patients with OCD and 29 healthy age-, gender- and education level- matched volunteers, collected in our hospital from January 2013 to December 2014, underwent RS-fMRI. An approach of ALFF and fALFF was used to compare resting-state activity between the two groups. Subsequently, correlation analysis was performed between ALFF and fALFF values in significantly altered brain regions and Yale-Brown Obsessive Compulsive Scale （Y-BOCS） scores of the OCD patients. Results As compared with healthy volunteers, the OCD patients had significantly reduced ALFF values in the right precuneus, and significantly reduced fALFF values in the right precuneus and the left middle temporal gyms （P〈0.05）. The ALFF values and fALFF values in the right precuneus and the fALFF values in left middle temporal gyms had no significant correlation with Y-BOCS scores of the OCD patients （r=-0.130, P=-0.518; r=-0.270, P=-0.173; r=-0.041, P=-0.839）. Conclusion ALFF and fALFF changes in the right precuneus and fALFF changes in the left middle temporal gyms are associated with pathophysiology mechanism of OCD, and these values is not correlate with symptom severity of OCD.

关 键 词：强迫症 静息态功能磁共振成像 低频振幅 低频振幅比率 

分 类 号：R749.7[医药卫生—神经病学与精神病学]