三阴性乳腺癌与非三阴性乳腺癌COMT、APOE基因多态性的差异性研究  

Differential research on COMT,APOE polymorphisms in triple-negative breast cancer and non-triple negative breast cancer patients

作　　者：李文[1] 甘辰 张博[1] 程怀东[1] 

机构地区：[1]安徽医科大学第二附属医院肿瘤科,合肥230601

出　　处：《安徽医科大学学报》2017年第2期277-280,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81372487)

摘　　要：目的探讨三阴性乳腺癌(TNBC)与非三阴性乳腺癌(NTNBC)患者COMT、APOE基因多态性的差异,从而解释化疗后认知障碍发生。方法对60例TNBC和60例NTNBC化疗后的患者进行COMT(rs165599、rs4680、rs737865),APOE(rs429358、rs7412)5个单核苷酸多态性(SNP)位点的等位基因频率、基因型频率检测。结果单位点分析结果表明,与NTNBC相比,TNBC在COMT(rs737865)位点上的等位基因分布(P=0.013),基因型分布(P=0.010)方面差异有统计学意义,而在APOE(rs429358,rs7412)方面两组差异无统计学意义。结论提示TNBC患者COMT基因的多态性可能是其化疗后认知障碍发生的易感性因子。Objective To investigate the differences of the C OMT （catechol-O-methyltransferase） and APOE （apo- lipoprotein E） gene polymorphisms in triple -negative breast cancer （TNBC） and non-triple negative breast cancer （NTNBC） patients, so as to explain the occurrence chemotherapy-induced cognitive impairment in breast cancer patients. Methods 60 TNBC and 60 NTNBC patients after chemotherapy respectively underwent five SNP loci al- lele frequency and genotype frequency detection on COMT （rs165599, rs4680, rs737865）, APOE （rs429358, rs7412）. Results Compared with NTNBC survivors, there was a significant difference in TNBC on the COMT （ rs737865 ） loci allele （P = 0. 013） and genotype （P = 0. 010） , and in respect of APOE （rs429358, rs7412） was no statistically significant differences between the two groups. Conclusion It indicates that the COMT gene poly- morphisms could be a susceptibility factor for cognitive dysfunction in TNBC survivors.

关 键 词：COMT APOE 基因多态性 化疗 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]