外泌体与肿瘤化疗耐药的研究进展  

Progress in research on exosomes in tumor chemotherapy resistance

作　　者：王爽[1] 孔祥玉[1] 杜利清[1] 

机构地区：[1]北京协和医学院&中国医学科学院放射医学研究所辐射效应室,天津300192

出　　处：《肿瘤》2017年第2期184-187,共4页Tumor

基　　金：国家自然科学基金资助项目(编号:81302803);天津市应用基础与前沿技术研究计划(编号:14JCYBJC28800)~~

摘　　要：肿瘤化疗耐药是肿瘤治疗中的一大难题,耐药机制与许多因素相关,其中肿瘤微环境是近些年的研究热点。外泌体是肿瘤微环境中细胞分泌的胞外囊泡,参与机体的生理和病理活动。许多研究表明,外泌体的分泌可以作为信号转导的媒介以改变肿瘤对化疗药物的敏感性,参与肿瘤进程。同时,对外泌体产生耐药的机制研究对于更好地认识和治疗肿瘤有所帮助。然而,目前对于肿瘤耐药与外泌体相关性的研究还处于初级阶段,许多问题尚待解答。本文对近年来肿瘤耐药与外泌体的研究进展进行综述。Tumor chemotherapy resistance is a big challenge in treatment. The resistance mechanism is related to many factors, including the tumor microenvironment. Tumor microenvironment is the research hotspot in recent years. Exosomes are extracellular vesicles, which can be secreted by most cells into the tumor microenvironment and take part in the physiological and pathological activity of organism. In recent years, more and more researches have indicated that the exosome can change tumor sensitivity to chemotherapy drugs and participate in the process of tumor as a medium for signal transduction. Meanwhile, the study on the resistance mechanism of exosome contributes to better understanding and treatment of the tumor. However, the study on correlation between chemotherapy resistance and exosome is still in the initial stage by now, and there are many questions are awaiting answers. This paper carries out a review on the progress in chemotherapy resistance and exosomes in recent years.

关 键 词：外泌体 肿瘤微环境 抗药性 肿瘤 肿瘤标志物 

分 类 号：R730.5[医药卫生—肿瘤]