循环肿瘤细胞存活调节机制及其靶向治疗策略的研究进展  

Progress in survival regulatory mechanism of circulating tumor cells and their targeted therapeutic strategies

作　　者：王文超[1,2] 施乐华[1,2] 殷正丰[1,2] 

机构地区：[1]第二军医大学东方肝胆外科医院分子肿瘤实验室,上海200438 [2]苏州大学医学部第一临床医学院,江苏苏州215123

出　　处：《肿瘤》2017年第2期188-194,共7页Tumor

基　　金：国家自然科学基金(编号:81272668;81272669);国家传染病重大专项基金(编号:2012ZX10002012-010)~~

摘　　要：循环肿瘤细胞(circulating tumor cells,CTCs)是指因自发或诊疗操作过程中进入外周血循环的肿瘤细胞,被普遍认为是肿瘤复发与转移的根源。近年来研究发现,CTCs可以通过克服血流剪切力的机械损伤、抵抗失巢凋亡以及逃避免疫杀伤,甚至对系统的化疗产生耐药等机制促进其在外周血中存活下来。本文从CTCs自身生物学特性及血液微环境两个方面就CTCs形成及迁移过程中涉及的存活机制进行综述,并探讨了针对CTCs存活机制的肿瘤治疗新策略的研究进展。Circulating tumor cells （CTCs） are a kind of tumor cells disseminated in the peripheral blood circulation due to spontaneous operation, diagnosis or treatment. CTCs have been regarded as crucial source of tumor recurrence and metastasis. The recent studies show that CTCs can survive in circulatory system through overcoming mechanical damage of blood shear stress, evading immune destruction, and resistance to anoikis and systemic chemotherapy drugs. In this paper, the possible survival mechanisms involved in CTCs formation and migration are reviewed according to their biological characteristics and blood microenvironment, while the latest progress in the novel strategies for tumor treatment targeting CTCs is discussed.

关 键 词：肿瘤细胞 循环 肿瘤逃逸 分子靶向治疗 

分 类 号：R730.21[医药卫生—肿瘤]