更昔洛韦眼用凝胶和阿昔洛韦滴眼液治疗病毒性角膜炎临床比较  

Clinical comparison of ganciclovir ophthalmic gel and acyclovir eye drops in the treatment of viral keratitis

作　　者：袁敏 黄利 游惠芬 冯慧艳 

机构地区：[1]东莞市樟木头医院五官科,523633 [2]东莞市樟木头医院检验科,523633

出　　处：《中国现代药物应用》2017年第1期10-12,共3页Chinese Journal of Modern Drug Application

摘　　要：目的比较更昔洛韦眼用凝胶和阿昔洛韦滴眼液对病毒性角膜炎的治疗效果。方法 92例病毒性角膜炎患者,随机分为对照组和观察组,各46例。对照组患者使用阿昔洛韦滴眼液治疗,观察组患者使用更昔洛韦眼用凝胶治疗,两组患者均治疗2周,对比两组的总有效率、用药期间的不良反应、用药后的症状改善情况以及停药后的复发率。结果观察组的治疗总有效率为93.4%,高于对照组的73.9%,差异有统计学意义(P<0.05)。用药1年后回访对照组复发率为23.9%,高于观察组的6.5%,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论在病毒性角膜炎的治疗中,应用更昔洛韦眼用凝胶的效果优于阿昔洛韦滴眼液,且药物的不良反应少,可将更昔洛韦眼用凝胶作为治疗病毒性角膜炎的首选用药。Objective To compare therapeutic effect of ganciclovir ophthalmic gel and acyclovir eye drops in the treatment of viral keratitis. Methods A total of 92 viral keratitis patients were randomly divided into control group and observation group, with 46 cases in each group. The control group received acyclovir eye drops for treatment, and the observation group received ganciclovir ophthalmic gel for treatment. Both groups had 2-week treatment and comparison were made on total effective rate, adverse reaction during drug use, symptoms improvement after drug use and recurrence rate after drug withdrawal. Results The observation group had higher total treatment effective rate as 93.4% than 73.9% in the control group and the difference had statistical significance（P〈0.05）. The control group had higher recurrence rate as 23.9% than 6.5% in the observation group after 1-year drug use, and the difference had statistical significance（P〈0.05）. There was no statistically significant difference in incidence of adverse reaction（P〉0.05）. Conclusion Ganciclovir ophthalmic gel has better effect than acyclovir eye drops in the treatment of viral keratitis, with little adverse reaction. Ganciclovir ophthalmic gel can be the first choice for the treatment of viral keratitis.

关 键 词：病毒性角膜炎 更昔洛韦凝胶 阿昔洛韦滴眼液 

分 类 号：R772.21[医药卫生—眼科]