有氧运动联合艾司西酞普兰对老年抑郁症患者的影响  

Effect of aerobic exercise combined with escitalopram on senile depressive patients

作　　者：王磊[1] 寿晓玲[2] 任爱华[2] 王志轩[1] 于恩彦[3] 吴万振[1] WANG Lei SHOU Xiaoling REN Aihua WANG Zhixuan YU Enyan WU Wanzhen(Department of Mental Health, Zhejiang Hospital, Hangzhou 310013, China Department of Cardiac Rehabilitation, Zhejiang Hospital, Hangzhou 310013, China Department of Mental Health, Zhejiang Provincial People＇s Hospital, Hangzhou 310014, China)

机构地区：[1]浙江医院精神卫生科,浙江杭州310013 [2]浙江医院心脏康复科,浙江杭州310013 [3]浙江省人民医院精神卫生科,浙江杭州310014

出　　处：《中国现代医生》2016年第35期78-81,85,共5页China Modern Doctor

基　　金：浙江省基层卫生适宜技术成果转化工程重大项目(2013T301-19)

摘　　要：目的 探讨有氧运动联合艾司西酞普兰对老年抑郁症患者预后的影响。方法 收集浙江医院精神卫生科就诊的老年抑郁症患者,随机分为有氧运动＋艾司西酞普兰组（E＋AE组）、普通运动＋艾司西酞普兰组（E＋NAE组）和艾司西酞普兰组（E组）,观察三组干预前及干预1个月、2个月、4个月、6个月后的疗效及汉密尔顿抑郁量表（HAMD）评分的变化情况。HAMD评分≤10分作为抑郁症状临床缓解的标准。结果 共有108例老年抑郁症患者随机入组,在研究末,E组中56.7%、E＋NAE组中63.0%、E＋AE组中80.0%获得临床缓解（χ2=12.8,P=0.002）。E＋AE组与E＋NAE组和E组比较,能在更短的时间内获得临床缓解（P〈0.05）。结论 老年抑郁症患者在药物治疗的基础上联合有氧运动安全有效。Objective To explore the effect of aerobic exercise combined with escitalopram on the prognosis of elderly patients with depression. Methods Elderly depressed patients admitted into department of mental health in Zhejiang Hospital were enrolled and randomly divided into three groups：aerobic exercise＋eseitalopram group （E＋AE group）, general exercise＋escitalopram group（E＋NAE group） and escitalopram group（E group）, and the changes of effect and HAMD score before and after the one month, two months ,four months and six months of intervention were observed. HAMD score ≤ 10 was as the standard of clinical remission of depressive symptoms. Results A total of 108 elderly depressive patients were randomly chosen into the groups.56.7% in the E group, 63.0% in the E＋NAE group and 80.0% in the E＋ AE group received a clinical remission（χ^2=12.8, P=0.002） at the end of the study period. E＋AE group achieved clinical remission in a shorter time compared with E＋NAE group and E group（P〈0.05）. Conclusion It is safe and effective to combine aerobic exercise on the basis of drug therapy in elderly patients with depression.

关 键 词：有氧运动 老年抑郁症 汉密顿抑郁量表 临床缓解 

分 类 号：R749.4[医药卫生—神经病学与精神病学]