同步放化疗治疗老年局限期小细胞肺癌效果观察  

Effects Observation of Radiotherapy Combined with Chemotherapy in Treatment of Elderly Patients with Limitedstage Small Cell Lung Cancer

作　　者：陈连刚[1] 侯春立[1] 王梓华[1] 胡兴茂[1] 刘建坤[1] 张怡梅[1] 赵青兰[1] 朱铁年[1] 

机构地区：[1]解放军白求恩国际和平医院肿瘤科,石家庄050082

出　　处：《临床误诊误治》2017年第2期90-94,共5页Clinical Misdiagnosis & Mistherapy

基　　金：河北省医学科学研究重点课题计划(20130014)

摘　　要：目的观察同步放化疗治疗老年局限期小细胞肺癌(limited-stage small cell lung cancer,LSCLC)的效果。方法选取2008年1月—2013年1月解放军白求恩国际和平医院肿瘤科收治的符合纳入及排除标准的LSCLC65例,根据治疗方案不同分为试验组(采用同步放化疗,35例)和对照组(采用单纯化学治疗,30例)两组,观察比较两组近远期临床疗效及治疗不良反应。结果总有效率试验组为82.9%高于对照组56.7%,两组比较差异有统计学意义(P<0.05)。中位生存期及1、2、3年生存率试验组分别为26个月及74.3%、53.7%、34.1%高于对照组20个月及52.3%、32.2%、13.4%,差异均具有统计学意义(P<0.05)。两组治疗过程中总不良反应发生率比较差异无统计学意义(P>0.05)。结论同步放化疗治疗老年LSCLC具有较好的近远期疗效,且总不良反应发生率与采用单纯化学治疗的老年LSCLC相当。Objective To observe effects of radiotherapy combined with chemotherapy in treatment of elderly patients with limited-stage small cell lung cancer （ LSCLC）. Methods A total of 65 LSCLC patients admitted during January 2008 and January 2013 were recruited according to the study criteria, and the patients were divided into study group （n = 35 ） and control group （ n = 30） according to therapeutic methods. Study group was treated with synchronous radiotherapy combined with chemotherapy, while control group was treated with chemotherapy alone. Short and long-time clinical efficacy and adverse reaction in two groups were observed and compared. Results The total effective rate was higher in study group （82.9%） than 56.7% in control group, and the difference was statistically significant （P 〈 0.05）. Median survival time （MST） was 26 months, and the time was significantly longer than 20 months in control group ; survival rates in 1st, 2nd and 3rd years were 74.3% , 53.7 % and 34.1% respectively, and the rates were significantly higher than 52.3% , 32.2% and 13.4% respec- tively in control group （ P 〈 0.05 ）. There was no significant difference in incidence rate of adverse reaction during treatment between two groups （P 〉 0.05 ）. Conclusion radiotherapy combined with chemotherapy has better short and long-time clini- cal efficacy in treatment of elderly patients with limited-stage small cell lung cancer, and the total incidence rate of adverse reaction is similar to that by chemotherapy alone.

关 键 词：小细胞肺癌 老年人 放射治疗 化学治疗 

分 类 号：R734.2[医药卫生—肿瘤]