癌睾丸抗原在乳腺癌中的研究进展  

Role of Cancer Testis Antigen in Breast Cancer

作　　者：徐碧荷[1,2] 薛昀[2] 陈晓芹[3] 肖蓉心 李彬[2] 隋锡朝[4] 丁玲昱 焦运燊 阴凯麟 李欢欢[1,2] 高子蕊 陈曦[1,2] 郭丽凯 王倩倩[1,2] 冯金秋[1,2] 王月丹[1,2] 初明[1,2] 无 

机构地区：[1]北京大学医学部基础医学院,北京100191 [2]卫生部医学免疫学重点实验室,北京100191 [3]重庆涪陵中心医院,重庆408000 [4]首都医科大学燕京医学院,北京101300 [5]北京大学人民医院,北京100044

出　　处：《转化医学电子杂志》2017年第2期1-4,共4页E-Journal of Translational Medicine

基　　金：国家自然科学基金资助项目(81603119);北京市自然基金项目(7174316);北京市重点学科基础医学学科建设项目(BMU20110254);北京市自然科学基金资助项目(7162099);深圳市科技项目资助项目(JCYJ20150403110829615);重庆市科委课题资助项目(cstc2013jcyj A10023);首都医科大学自然科学基金(2014ZR25)

摘　　要：癌睾丸抗原(CTA)是一类特异性较高的肿瘤抗原,只在多种恶性肿瘤和睾丸表达.CTA能作为靶点,诱导吞噬性T细胞介导的CTL免疫反应,而正常含有CTA的睾丸细胞中因缺少MHCⅠ类分子而避免免疫系统的攻击.乳腺癌是女性最常见的恶性肿瘤之一,并在引起死亡的疾病中位居前列.乳腺癌中存在的CTA对乳腺癌治疗方法的发展有着重大的意义.本文围绕乳腺癌中CTA的表达,CTA的功能以及对于乳腺癌治疗的价值作此综述.Cancer-testis antigen is a kind of cancer antigen with highly restricted expression. It is expressed in a wide variety of malignant tumors but it’s expression in normal tissue is mostly restricted to germ cells of the testis. CTAs can elicit immune response mediated by cytotoxic T lymphocytes,while testis cells miss the attack due to the lack of MHC class 1 molecules. Breast cancer is one of the most common and death- related diseases among women. Nevertheless,the incidence of CTAs in breast cancer brings hope to the development of breast cancer therapy. In this review,we briefly described the expression of CTAs in breast cancer,and summarized the biological function of CTAs as well as the value of applying CTAs to breast cancer immunotherapy.

关 键 词：癌睾丸抗原 乳腺癌 靶点 凋亡 免疫应答 

分 类 号：R737.9[医药卫生—肿瘤]