肺癌与HPV感染相关性的初步研究  

Primary study on the correlation between lung cancer and HPV infection

作　　者：姚丽[1] 巩丽[1] 朱少君[1] 韩秀娟[1] 兰淼[1] 张伟[1] 

机构地区：[1]第四军医大学唐都医院病理科,陕西西安710038

出　　处：《转化医学电子杂志》2017年第2期46-47,共2页E-Journal of Translational Medicine

基　　金：陕西省自然科学基础研究计划项目(2013JQ4039)

摘　　要：目的:应用液相芯片技术分析肺癌患者与HPV感染的相关性.方法:重组质粒表达HPV16 E6和E7蛋白,同微球偶联后作为抗原,应用Luminex系统检测肺癌患者血清中的相应抗体.结果:肺癌组HPV16 E6/E7抗体水平显著高于正常对照组,肺鳞状细胞癌与腺癌肿瘤组对比,肺鳞状细胞癌HPV16E6/E7抗体阳性率显著高于肺腺癌组,差异具有统计学意义(P<0.05).结论:HPV感染与肺鳞状细胞癌具有一定的相关性,为进一步研究肺鳞状细胞癌发生的分子机制提供了依据.AIM： To analyze the correlation between lung cancer and HPV infection by Luminex technology. METHODS： HPV16E6 / E7 proteins binding to microparticle were expressed with recombinant plasmid. The corresponding antibodies in serum of patient with lung cancer were detected by Luminex technology.RESULTS： The level of HPV16 E6 / E7 antibodies in lung cancer group were significantly higher than those of normal control group,and the difference was statistically significant（ P〈0.05）. The antibody positive rate of HPV16 E6 / E7 in squamous cell carcinoma of lung group was significantly higher than that of adenocarcinoma group,and the difference was statistically significant（ P 〈 0. 05）. CONCLUSION： There was a correlation between HPV infection and lung squamous cell carcinoma,which will be helpful for the further study of molecular mechanism of lung squamous cell carcinoma.

关 键 词：肺癌 HPV 液相芯片 

分 类 号：R737.33[医药卫生—肿瘤]