培美曲塞联合顺铂致1例肺癌患者急性肾功能衰竭合并Ⅳ度骨髓抑制的不良反应分析与药学监护  

Analysis on the adverse drug reactions and pharmaceutical care for one case of lung cancer patient with acute kidney failure and Ⅳ degree bone marrow depression caused by Pemetrexed plus Cisplatin

作　　者：石蕊[1] 王保信[2] 李立[1] 卢丹丹[1] 潘丹[1] 邹庆华[2] 赵可新[1] 

机构地区：[1]中国石油天然气集团公司中心医院药学部,河北廊坊065000 [2]中国石油天然气集团公司中心医院肿瘤科,河北廊坊065000

出　　处：《中国医药导报》2017年第2期170-174,共5页China Medical Herald

摘　　要：临床药师积极参与1例中晚期肺腺癌并颈部淋巴结转移高龄患者的治疗。根据患者病理诊断结果、功能状态评分及心、肝、肾功能评估,参与制订的化疗方案为培美曲塞(第1天,500 mg/m^2)+顺铂(第1~3天,25 mg/m^2)。患者于化疗第3天出现腹泻以及白细胞报危急值伴发热,第7天出现急性肾功能衰竭,第8~10天血小板报危急值。临床药师协助医师在抗菌药物选择、不良反应应对上提供药物治疗措施,将不良反应的危害降到最低。本文首次报道该化疗方案在治疗短时间内发生急性肾衰竭合并Ⅳ度骨髓抑制的严重不良反应。临床药师应在工作中参与制订肿瘤患者的治疗方案,并规范临床医师对化疗药物及其辅助用药的使用,减少因用药不规范产生的不良反应。Clinical pharmacists carried on the treatment for an elderly patient with advanced lung adenocarcinoma and developed in lymph node of neck. According to the results of pathologic diagnosis, performance status scores, function of cardiac, hepatic and kidney, the assigned chemotherapy plan was Pemetrexed （500 mg/m2, dl） ＋ Cisplatin （25 mg/m2, d2-4）. The diarrhea and critical value of white blood count combined with fever, acute kidney failure and the critical value of platelet happened respectively at the third, seventh day and eighth to tenth day after chemotherapy. Clinical pharmacists assisted on choosing the antimicrobial agents for preventing infection and dealing with the adverse drug re- actions, so as to decrease the danger of adverse reactions to the lowest. It is the first time to report that this chemother- apy can lead to acute kidney failure and IV degree bone marrow depression in 1 cure cycle. Making the treatment strat- egy for tumor patients and using regularly of chemotherapeutic drugs should be included in the clinical pharmacists＂ working plan, which will be helpful to reduce the adverse drug reactions caused by the haphazard drug treatment.

关 键 词：不良反应 培美曲塞 顺铂 肺癌 急性肾功能衰竭 Ⅳ度骨髓抑制 

分 类 号：R734.2[医药卫生—肿瘤]