卡培他滨联合奥沙利铂对于进展期大肠癌的化疗疗效观察  

Observation on chemotherapeutic effect of capecitabine combined with oxaliplatin in the treatment of advanced colonic cancer

作　　者：薛清萍 张世强 王保庆 

机构地区：[1]徐州矿务集团总医院肿瘤内科,221006

出　　处：《中国实用医药》2016年第36期99-101,共3页China Practical Medicine

摘　　要：目的探讨进展期大肠癌患者采用卡培他滨联合奥沙利铂化疗方案的临床效果。方法 58例进展期大肠癌患者,按照接受化疗方案的不同分为XELOX组和5-FU/LV组,各29例。XELOX组采用卡培他滨联合奥沙利铂化疗方案;5-FU/LV组采用5-氟尿嘧啶联合亚叶酸钙方案,两组均接受2个以上周期的化疗。第1年每6个月进行1次随访复查,此后每年随访复查1次,评价两组的化疗疗效和不良反应。结果 XELOX组总有效率、3年无病生存率、中位生存时间分别为89.7%、86.2%、（41.72±5.65）个月均优于5-FU/LV组的65.5%、62.1%、（37.48±4.35）个月,差异有统计学意义（P〈0.05）。XELOX组发生外周神经病变明显多于5-FU/LV组,而胃肠道反应、骨髓抑制明显少于5-FU/LV组,差异有统计学意义（P〈0.05）。两组患者不良反应均为Ⅰ-Ⅱ级,行对症处理后均好转,对化疗不构成影响。结论进展期大肠癌患者采用卡培他滨联合奥沙利铂化疗方案疗效较好,不良反应较少,患者耐受性好。Objective To explore clinical effect of capecitabine combined with oxaliplatin in the treatment of advanced colonic cancer. Methods A total of 58 advanced colonic cancer patients were divided by different chemotherapy regimens into XELOX group and 5-FU/LV group, with 29 cases in each group. The XELOX group had capeeitahine combined with oxaliplatin as chemotherapy regimens, and the 5-FU/ LV group received 5-fluorouracil combined with calcium folinate regimens. Both groups received 2 cycles or above chemotherapy. Every 6 months for a follow-up review in the first year, then follow-up review once a year. Evaluation were made on chemotherapeutic effect and adverse reactions. Results The XELOX group had total effective rate, disease free survival in 3 year and median survival time respectively as 89.7%, 86.2% and （41.72 ± 5.65）months, which were all better than 65.5%, 62.1% and （37.48 ± 4.35）months in the 5-FU/LV group, and their differences had statistical significance （P〈0.05）. The XELOX group had much more eases with peripheral neuropathy than the 5-FU/LV group, and less cases with gastrointestinal reaction and myelosuppression than the 5-FU/LV group. Their differences had statistical significance （P〈0.05）. Both groups had adverse reaction degree of I - II, and all relived after expectant treatment, which had no influence on chemotherapy. Conclusion Capecitabine combined with oxaliplatin as chemotherapy regimens provides good effect in the treatment of advanced colonic cancer, with little adverse reactions and good tolerance.

关 键 词：卡培他滨 进展期大肠癌 奥沙利铂 化疗 

分 类 号：R735.2[医药卫生—肿瘤]