血清ACE及CRP在肝硬化疾病中的临床意义  

Clinical significance of serum ACE and CRP in patients with liver cirrhosis

作　　者：张国光[1] 容海燕 

机构地区：[1]桂林医学院第二附属医院检验科,广西桂林541199

出　　处：《华夏医学》2016年第6期30-33,共4页Acta Medicinae Sinica

摘　　要：目的:检测血清血管紧张素转化酶(ACE)活性及C反应蛋白(CRP)浓度的变化,探讨其在肝硬化疾病中的应用价值。方法:采用罗氏C501全自动生化分析仪对各组样本进行ACE和CRP的测定。根据肝功能Child-Pugh分级标准将192例肝硬化患者分为3组:A组(A级)50例、B组(B级)82例、C组(C级60例)作为观察组,并以120例健康者作为对照组。结果 :肝硬化组血清ACE活性与CRP水平较健康对照组显著升高,差异有统计学意义(P<0.01),且随Child-Pugh分级异常程度逐渐升高,A,B,C级间两两比较差异有统计学意义(P<0.01)。以ACE高于65 U/L为临界点,高ACE组CRP水平明显高于低ACE组CRP的含量。结论:血清ACE活性与CRP浓度检测有助于肝硬化疾病的诊断、监测、疗效观察及预后判断。Objective：To investigate the changes of serum angiotensin converting enzyme （ACE） activity and the concentration of C reactive protein （CRP）, and to explore its application value in liver cirrhosis. Methods： Samples of ACE and CRP for each groups were determined by using Roche C501 automatic biochemical analyzer. According to the Child-Pugh classification of liver function standard, 192 cases of liver cirrhosis were divided into 3 observation groups： 50 cases in Group A （level A）, 82 cases in Group B （level B）, and 60 cases in Group C （level c）, and another 120 cases of healthy subjects were selected as the control group. Results： The serum ACE and CRP levels in liver cirrhosis group were significantly higher than those of the healthy control group, which were of statistical differences（P〈0.01）, and with abnormal degree of the Child-Pugh classification gradually increased, there were statistical differences between level A, B, and C （P〈0.01）. With ACE higher than 65 U/L as the critical point, level of CRP in group ACE was significantly higher than that of the tow ACE group. Conclusion： Detection of serum ACE activity and CRP concentration is helpful for the diagnosis, monitoring, observation of curative effect and prognosis of liver cirrhosis patients.

关 键 词：血管紧张素转化酶 C反应蛋白 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]