诱导化疗联合同步放化疗治疗鼻咽癌的临床效果观察  

Observation of clinical effect by induction chemotherapy combined with concurrent radiochemotherapy in the treatment of nasopharyngeal carcinoma

作　　者：杨东红[1] 陈华林[1] 罗海清[1] 李淑慧[1] 王永存[1] 

机构地区：[1]广东医学院附属医院肿瘤中心,524001

出　　处：《中国实用医药》2016年第3期10-11,共2页China Practical Medicine

摘　　要：目的研究分析诱导化疗与同步放化疗联合治疗鼻咽癌的临床疗效。方法64例鼻咽癌患者，根据数字表法将其随机分为观察组和对照组，每组32例。对照组患者给予同步放化疗，观察组实行诱导化疗联合同步放化疗。观察两组临床效果。结果两组近期鼻咽肿瘤治疗有效率和2年局部控制率比较差异无统计学意义（P〉0．05）。观察组无远处转移生存率（90．63％）明显高于对照组（68．75％），差异有统计学意义（X^2=4．206，P〈0．05）。在不良反应上对照组患者更容易发生贫血，两组血红蛋白降低比率比较差异有统计学意义（P〈0．05）。结论诱导化疗联合同步放化疗与单纯同步放化疗近期疗效相当，远期疗效优越，不良反应可耐受。Objective To research and analyze clinical effect by induction chemotherapy combined with concurrent radiochemotherapy in the treatment of nasopharyngeal carcinoma. Methods A total of 64 patients with nasopharyngeal carcinoma were divided by random number table into observation group and control group, with 32 cases in each group. The control group received concurrent radiochemotherapy, and the observation group received induction chemotherapy combined with concurrent radiochemotherapy. Clinical effects of the two groups were observed. Results There were no statisticaUy significant differences of short-term effective rate in treating nasopharyngeal carcinoma and 2-year local control rate between the two groups （P〉0.05）. The observation group had much higher non-distant metastasis survival rate （90.63%） than the control group （68.75%）, and the difference had statistical significance （X2=4.206, P〈0.05）. The control group had higher possibility of anemia as adverse reaction than the observation group. The difference of reduced hemoglobin rate had statistical significance between the two groups （P〈0.05）. Conclusion Combination of induction chemotherapy and concurrent radiochemotherapy provides similar short-term effect as concurrent radiochemotherapy, while its long-term effect is better, along with tolerable adverse reactions.

关 键 词：诱导化疗 同步放化疗 鼻咽癌 疗效观察 

分 类 号：R739.63[医药卫生—肿瘤]