枸橼酸咖啡因药物动力学模型定量分析用药方案可行性  

The Quantitative Analysis of Therapeutic Regimen Feasibility Based on Caffeine Citrate Pharmacokinetics Model

作　　者：李冬梅[1] 张煜[1] 汪琪[2] LI Dong-mei ZHANG Yu WANG Qi(School of Applied Science, Harbin University of Science and Technology, Harbin 150080,China Heilongjiang Hospital, Harbin, 150056 China)

机构地区：[1]哈尔滨理工大学应用科学学院,黑龙江哈尔滨150080 [2]黑龙江省医院,黑龙江哈尔滨150056

出　　处：《数学的实践与认识》2017年第2期116-123,共8页Mathematics in Practice and Theory

基　　金：黑龙江省自然科学基金项目(A2016004)

摘　　要：基于枸橼酸咖啡因标准用药方案,结合临床用药经验设计了三种常规用药方案及两种个性用药方案.利用药物动力学模型给定的血药浓度随时间变化规律,以有效治疗浓度为判据,分析了方案的可行性.结合临床用药案例分析了有效用药周期.This paper is based on the standard therapeutic regimen of caffeine citrate,three conventional regimens and two personality regimens are designed by combining clinical medcine experience.Pharmacokinetics model gives blood drug concentration variation law with time,the feasibility of the scheme was analyzed,the effictive medication cycle is obtained in according to the clinical case.

关 键 词：枸橼酸咖啡因 用药方案 药物动力学模型 

分 类 号：R969.1[医药卫生—药理学]