小叶薜荔根茎提取物抗α-葡萄糖苷酶及乙酰胆碱酯酶活性研究  

α-Glucosidase and Acetylcholinesterase Inhibitory Potency of Extract from Rhizome of Ficus pumila L.

作　　者：王娟[1,2] 覃景芳 柳春艳[1,2] 唐煌[1,2] 

机构地区：[1]广西师范大学化学与药学学院,广西桂林541004 [2]广西师范大学省部共建药用资源化学与药物分子工程国家重点实验室,广西桂林541004

出　　处：《广西师范大学学报（自然科学版）》2017年第1期69-74,共6页Journal of Guangxi Normal University:Natural Science Edition

基　　金：国家自然科学基金(81260471);广西医药产业人才小高地项目(1203)

摘　　要：以芦丁为标准品测定小叶薜荔根茎提取物中黄酮的含量,利用96微孔板法测定提取物对α-葡萄糖苷酶以及乙酰胆碱酯酶(AChE)的抑制作用。结果表明:小叶薜荔根茎提取物中黄酮质量分数为0.8%~7.1%,提取物对α-葡萄糖苷酶抑制IC50值达到0.018g/L,对AChE抑制IC50值达到0.133g/L。粗提物的总黄酮含量与抗α-葡萄糖苷酶能力之间具有较为明显的相关性。The extracts obtained from rhizome of Ficus pumila L. were evaluated for its yield of total flavonoids by standard sample rutin. Their α-glucosidase and acetylcholinesterase （ACHE） inhibitory potency were also explored by the 96-micro-plate-based method. The regult showed that the total flavonoids content of the extracts ranged from 0.8 % to 7.1 % and the extracts had high inhibitory activity toward α-glucosidase and AChE with IC50 values are up to 0.018 g/L and 0.133 g/L respectively. A clear correlation between the total flavonoids content and α-glucosidase inhibitory activity was found.

关 键 词：Α-葡萄糖苷酶 黄酮 乙酰胆碱酯酶 小叶薜荔 

分 类 号：O629[理学—有机化学]