不同治疗方案对老年胶质母细胞瘤患者生存期的影响  

The prognostic effects of different therapeutic regimens on survival of senile patents with glioblastoma

作　　者：朱正权[1] 张继[2] 陈正和[2] 刘亮[1] 张达旻 杜山别克·克孜 夏海成[1] 

机构地区：[1]新疆医科大学附属肿瘤医院神经外科,新疆乌鲁木齐830011 [2]中山大学肿瘤防治中心神经外科/神经肿瘤科、华南肿瘤学国家重点实验室、癌症医学协同创新中心,广东广州510060

出　　处：《广东医学》2017年第1期33-37,共5页Guangdong Medical Journal

摘　　要：目的研究不同治疗方案对老年胶质母细胞瘤患者生存期的影响。方法采用单因素生存分析法,生存曲线的比较采用log-rank检验,多因素生存分析采用Cox回归模型,分析治疗方案、年龄、是否服用替莫唑胺、KPS评分、肿瘤部位、大小等因素对生存时间的影响。结果通过单因素生存分析,老年胶质母细胞瘤患者的生存期与其治疗方案(放疗、手术局部切除、手术全部切除)、年龄(≤75岁、>75岁)、是否服用替莫唑胺、KPS评分(<70分、70~90分、>90分)等因素有关(P<0.05);而生存期与肿瘤部位(额、颞、顶、枕叶)、大小(≤4 cm、>4 cm)无关(P>0.05)。多因素分析:治疗方案为手术全部切除、服用替莫唑胺、KPS评分越高(<70分、70~90分、>90分)等因素为老年胶质母细胞瘤患者的生存期保护因素(P<0.05);而年龄越大则表现为危险因素(P<0.05)。生存期与肿瘤部位(额、颞、顶、枕叶)、大小(≤4 cm、>4 cm)等因素的分析提示差异无统计学意义(P>0.05)。结论治疗方案为手术全部切除、服用替莫唑胺、KPS评分越高(<70分、70~90分、>90分)等因素为老年胶质母细胞瘤患者的生存期的保护因素;年龄越大则表现为危险因素。肿瘤大小及肿瘤部位对中位生存时间无明显影响。Objective To study the influence of different therapeutic regimens on the survival of senile glioblastoma（ GBM） patients. Methods This study used Single factor survival analysis,and Log- rank test was used to compare the survivals. Multivariate survival analysis was performed using Cox regression model,and P〈0.05 was considered statistically significant. Results According to single factor survival analysis,the survival time for senile glioblastoma patients was significant correlated with the therapeutic regimens（ radiotherapy,partial removal surgery,total removal surgery）,age（=75 years or75 years old）,temozolomide treatment,KPS score（70 points,70-90 points,or90points）（P〈0.05）. However,it had no significant correlation with the location（ frontal,temporal,parietal or occipital lobe） or the size（=4 cm or4 cm）（P〈0.05）. According to multivariate survival analysis,the en bloc tumor resection,temozolomide treatment,and higher KPS score were considered as protective factors for survival time in these population（P〈0.05）; as old age was a risk factor for lifetime. Conclusion For senile patients with glioblastoma,en bloc resection,temozolomide treatment,higher KPS scores are protective factors for the survival time; while advanced age was a risk factor. There is no correlation between the tumor size or tumor location with the median survival lifetime.

关 键 词：老年 胶质母细胞瘤 生存期 治疗方案 

分 类 号：R730.264[医药卫生—肿瘤]