原发性癫痫患儿脑电图与血清炎性因子水平的相关性分析  

Correlation analysis of EEG and serum levels of inflammatory factors in children with idiopathic epilepsy

作　　者：韩洁[1] 平莉莉[2] 胡丽敏[3] 侯晓英[1] 

机构地区：[1]河北省邯郸市中心医院功能科,河北邯郸056001 [2]河北省邯郸市中心医院新生儿科,河北邯郸056001 [3]河北省邯郸市中心医院儿科,河北邯郸056001

出　　处：《河北医科大学学报》2017年第1期51-55,共5页Journal of Hebei Medical University

摘　　要：目的分析原发性癫痫患儿脑电图与血清炎性因子水平的相关性。方法将75例原发性癫痫患儿根据癫痫发作情况分为癫痫频发组、癫痫持续状态组、非癫痫频发非持续状态组各25例。另选取同期30例健康体检儿童作为对照组。观察对照组和癫痫患儿血清高迁移率族蛋白B1(high-mobility group protein box-1,HMGB1)、白细胞介素2(interleukin-2,IL-2)、白细胞介素6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)水平及脑电图检查结果。结果癫痫患儿HMGB1、IL-2、IL-6、TNF-α及脑电图异常率均明显高于健康对照组(P<0.05),癫痫持续状态组、癫痫频发组血清HMGB1、IL-2、IL-6、TNF-α水平均高于非癫痫频发非持续状态组(P<0.05);脑电图癫痫样放电组及慢波异常组血清中HMGB1、IL-2、IL-6、TNF-α水平明显高于脑电图正常及界线性组(P<0.05),脑电图癫痫样放电组血清中HMGB1、IL-2、IL-6、TNF-α水平明显高于脑电图慢波异常组(P<0.05)。结论血清HMGB1、IL-2、IL-6、TNF-α是影响原发性癫痫患儿病情的重要炎性因子,脑电图异常改变与炎症因子表达水平呈正相关。Objective To analyze the relevance of EEG in children with idiopathic epilepsy to serum levels of inflammatory factors. Methods Seventy-five cases diagnosed with idiopathic epilepsy included in the study were divided into 3 groups according to the frequency of epileptic seizures： epilepticus status group, non-epileptic frequent or persistent state group, and persistent state group, which included 25 cases in each group. Thirty healthy children were enrolled as control cases. Serum level of inflammatory factors （HMGB1, IL-6, IL-2, TNF-α） and EEG findings were analyzed in both epilepsy and control groups. Results Serum level of HMGB1, IL- 2, IL-6, TNF-α in in cases with epilepsy were significantly higher than that in control group （P〈0.05）, serum level of HMGB1, IL-2, IL-6, TNF-α in cases with epilepticus status and frequent epilepsy were both higher than that in non-frequent seizures or persistent state group （P〈0. 05）; Serum level of HMGB1, IL-2, IL-6, TNF-α in cases with EEG epileptic discharge and slow waves were significantly higher than those with normal EEG and boundary resistance （P〈0.05）. Serum level of HMGB1, IL-2, IL-6, TNF-α levels in cases with EEG epileptic discharge were significantly higher than those with EEG slow waves （P〈0.05）. Conclusion HMGB1, IL-2, IL-6, TNF-α are important inflammatory factors relevance to idiopathic epilepsy. Abnormalities findings in EEG were positively correlated with serum levels of HMGB1, IL-2, IL- 6, TNF-α.

关 键 词：癫痫 炎性因子 脑电描记术 儿童 

分 类 号：R742.1[医药卫生—神经病学与精神病学]