Twist基因在非小细胞肺癌中的研究进展  

Progress of Twist gene in non-small cell lung cancer

作　　者：李春雨[1] 曲仪庆[1] 

机构地区：[1]山东大学齐鲁医院呼吸科,济南250012

出　　处：《国际呼吸杂志》2017年第2期140-144,共5页International Journal of Respiration

基　　金：国家自然科学基金（81372333）

摘　　要：Twist作为碱性螺旋一环一螺旋转录因子的家族成员，在胚胎发育过程中通过转录激活或抑制下游靶基因对细胞的迁移和分化发挥重要的调节作用。Twist基因在多种肿瘤中存在高表达，参与多种信号通路及肿瘤上皮间质转化的调控，与肿瘤的发生、侵袭转移、血管生成、凋亡抵抗及肿瘤细胞耐药等密切相关，是多种肿瘤的不良预后因子。本文对Twist基因在非小细胞肺癌发生发展、侵袭转移及肿瘤细胞耐药等方面的研究进展作一综述。Twist, one of the basic helix-loop-helix protein （bHLH） family members, plays a crucial role on regulation of cell migration and differentiation in embryonic development by transcriptionally activating or suppressing its downstream target gene. Twist is over-expressed in a variety of human tumors and involves in the regulation of multiple signaling pathways and epithelial-mesenchymal transition in tumor. Moreover, Twist, as a poor prognosis factor, is associated with tumor genesis, invasion, metastasis, angiogenesis, resistance to apoptosis, multidrug resistance of tumor cells etc. This article reviews the research progress of Twist in tumorigenesis, development, invasion, metastasis, multidrug resistance of non small cell lung cancer.

关 键 词：TWIST基因 非小细胞肺癌 上皮一间质转化 侵袭 转移 

分 类 号：R734.2[医药卫生—肿瘤]