软组织肉瘤术中放疗的研究进展  

Intraoperative radiotherapy for soft tissue sarcoma

作　　者：聂芳芳[1] 付杰[1] 

机构地区：[1]上海交通大学附属第六人民医院肿瘤放疗科,上海医学硕士200233

出　　处：《医学研究生学报》2017年第2期208-211,共4页Journal of Medical Postgraduates

基　　金：上海市科学技术委员会科研计划项目(134119a9300)

摘　　要：软组织肉瘤是发生在结缔组织的恶性肿瘤,发病率低、种类多,多发生在四肢及腹膜后。手术联合术中放疗在提高软组织肉瘤疗效的同时还能保留功能,在肿瘤局部控制上占有明显优势。术中放疗可能会引发伤口感染、四肢缺血性坏死及纤维化等不良反应,但随着术中放疗设备逐渐发展应用,发生率会进一步降低。本文就软组织肉瘤术中放疗的历史发展、适应症及优越性、临床应用效果评价及不良反应等方面进行综述。Soft tissue sarcoma （STS） , which is mostly found in extremities and retroperitoneum, is a malignant tumor of the connective tissue with the low incidence （ 1% of all malignant tumors） and various kinds of histopathological types. Intraoperative radio- therapy （IORT） can improve the therapeutic effects of STS and to reserve the functions of the related organs, holding the apparent ad- vantage in local control rate of the tumor. IORT may cause toxicity, such as wound infections, limb ischemic necrosis and fibrosis. However, with the gradual development of IORT equipment, incidence rate of toxicity may be further reduced. This paper reviews the history, indications and advantages, clinical efficacy and adverse effect of IORT in STS.

关 键 词：软组织肉瘤 术中放疗 外照射 不良反应 

分 类 号：R738.6[医药卫生—肿瘤]