杞黄颗粒对肝肾阴虚型年龄相关性黄斑变性视力及眼底情况的影响  

Qihuang Granules on Vision and Fundus Situation of Age-Related Macular Degeneration

作　　者：孟梁[1] 梁凤鸣[2] 王燕 王莉[2] 黎红梅[2] 张欣桐[1] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193 [3]广州中医药大学第二附属医院,广东广州510260

出　　处：《辽宁中医杂志》2017年第2期285-288,共4页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(81173308)

摘　　要：目的:探讨杞黄颗粒对年龄相关性黄斑变性(AMD)患者视力及眼底情况,如色素上皮脱失情况、玻璃膜疣、新生血管及出血量的影响。方法:采用随机平行对照研究,将2010年6月—2014年6月在广东省中医院眼科及天津中医药大学第一附属医院眼科就诊的肝肾阴虚型年龄相关性黄斑变性患者随机分为实验组及对照组。最终入组120例患者,治疗组62例,予以杞黄颗粒口服;对照组58例,予以维生素C口服。治疗前后均对患者双眼视力及眼底情况进行记录,经过14周服药后,采用t检验和卡方检验对数据进行组间及组内的对比。结果:治疗前后两组组间患者总体视力差异无统计学意义(P>0.05),治疗前后两组组内对比有差异(P<0.05);干性AMD治疗前后视力的组间比较,差异均具有统计学意义(P<0.05),干性AMD治疗前后视力的组内比较,差异均具有统计学意义(P<0.05);湿性AMD治疗前后视力的组间比较,差异均具有统计学意义(P<0.05),湿性AMD治疗前后视力的组内比较,差异均具有统计学意义(P<0.05);干性AMD患者的眼底色素上皮及玻璃膜疣治疗前,组间比较差异无统计学意义(P>0.05),治疗后两组组间比较差异有统计学意义(P<0.05),治疗前后两组组内对比,差异有统计学意义(P<0.05);湿性AMD患者的的眼底出血及新生血管治疗前后,组间比较差异无统计学意义(P>0.05),治疗前后两组组内对比,差异有统计学意义(P<0.05)。结论:杞黄颗粒和维生素C对肝肾阴虚型年龄相关性黄斑变性的总体视力均有改善作用,且两者疗效相当;杞黄颗粒和维生素C对于干性AMD或湿性AMD患者的视力均有一定的改善作用;杞黄颗粒和维生素C均可改善干性AMD及湿性AMD患者的眼底情况,对于干性AMD患者眼底色素上皮及玻璃膜疣改善情况,两者疗效有差异,对于湿性AMD患者眼底出血及新生血管眼底改善情况,两者疗效相当;对于个别指标治疗前组间对比存Objective：To study the influence of Qihuang Granules on vision and fundus situation, such as pigment epithelium, drusen, hemorrhage and choroidal neovascularizationin patients with age - related macular degeneration （ AMD ）. Methods ： The trial design was random ,openand parallel controlled. On the other hand, 120 patients were randomly divided into experimental group and control group. All of 120 patients were liver - kidney Yin deficiency type of age - related macular degeneration in Guangdong Province Hospital of TCM and First Teaching Hospital of Tianjin University of TCM during June 2010 - June 2014. In the end, we divided 120 patients into experiment group 62 patients with Qihuang Granules and control group 58 patients with vitamin C and we recorded their vision and fundus situation when they took medicine 3 months. What＇s more, all data was processed by rank sum test between experimental group and control group. Results ： The differences of the overall vision before and after treatment of the two groups were not statistically significant （ P 〉 0. 05 ）. But there were significant differences of the overall vision in the same group before and after treatment （ P 〈 0. 05 ）. The differences of the overall vision between dry - AMD and wet - AMD were statis- tically significant before and after treatment（ P 〈 0. 05 ）. What＇s more, the overall visionresult was the same in the same group before and after treatment （ P 〈 0. 05 ）. In dry - AMD patients, the differences about pigment epithelium and drusen of the two groups were not statistically significant before treatment（P 〉 0. 05）. But there wee significant differences of pigment epithelium and drus- en in the two groups after treatment（ P 〈 0. 05 ）. There were significant differences of pigment epithelium and drusen in Qihuang Granules and vitamin C groups before and after treatment（ P 〈 0. 05 ）. In wet - AMD patients, the differences of hemorrhage and choroidal neovascularization before and after treatment

关 键 词：杞黄颗粒 年龄相关性黄斑变性 视力 眼底情况 

分 类 号：R774.5[医药卫生—眼科]