高原脑水肿发病机制及药物作用分子机制研究进展  

Research Progress of Pathogenesis and Drug Action Mechanism of High Altitude Cerebral Edema

作　　者：张新龙[1] 李文华[1] 任军[2] 

机构地区：[1]西藏民族大学医学部生命科学基础实验室,陕西省咸阳市712082 [2]兰州大学第二医院神经外科,甘肃省兰州市730030

出　　处：《中国全科医学》2017年第5期622-627,共6页Chinese General Practice

基　　金：国家自然科学基金资助项目(81360299)

摘　　要：随着平原人群初次或多次往返高原逐渐频繁,高原脑水肿(HACE)以病情发展迅速,病死率较高,逐渐受到人们的重视。近年来,从血流动力学、分子机制以及药物作用机制等方面对HACE的研究出现新的成果,本文通过总结与分析既往文献,就此进行综述。但由于HACE小鼠模型较难建立,导致关于HACE的诸多研究难以开展,HACE发病的病理生理机制至今还未完全阐明。As the roundtripping between plain Jnd the highland among the population tot the first time or many times are more and more frequently, high altitude cerebral edema （HACE） , with rapid disease development and high mortality, is gradually receiving the attention from people. In recent years, researches from the aspects of hemodynamics, molecular mechanism and drug action mechanism have made new achievements on HACE. The paper summarized and analyzed the previous literatures and made a review on them. However, due to the diffieulties in establishing of HACE mouse model, it is hard to carry out certain researches related to HACE and the pathogenesis of HACE has not been tully clarified until now.

关 键 词：脑水肿 高原病 血流动力学 血脑屏障 药理作用 

分 类 号：R742[医药卫生—神经病学与精神病学]