白芍总苷对比维生素B2治疗复发性阿弗他溃疡的疗效及不良反应  

Efficacy and adverse reaction of total glucosides of paeony compared with vitamin B2 in recurrent aphthous ulcers

作　　者：姚旭飞[1] 季育[1] 吴喆敏 

机构地区：[1]丽水市中医院口腔科

出　　处：《中国生化药物杂志》2017年第1期66-67,70,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医药卫生一般研究计划（2015KYB205）

摘　　要：目的 分析白芍总苷对比维生素B2在治疗复发性阿弗他溃疡（recurrent aphthous ulcer,RAU）中的临床疗效,并探讨不良反应。方法选取RAU患者120例,随机分成维生素B2组、白芍总苷组,每组60例。白芍总苷组饭后服用白芍总苷胶囊,3次/天,0.6g/d;维生素B2组饭后服用维生素B2片,3次/天,5mg/d,2组均治疗8周。观察溃疡变化、视觉模拟评分（visual analogue scale,VAS）及疗效。结果 2组患者治疗后VAS评分均明显降低,且白芍总苷组效果更显著（P〈0.05）。白芍总苷组治疗总有效率高于维生素B2组,2组间比较差异有统计学意义（P〈0.05）。白芍总苷组有轻微不良反应,维生素B2组无明显不良反应。结论 白芍总苷在治疗复发性阿弗他溃疡时,疗效好,安全性高。白芍总苷比维生素B2的治疗效果显著。Objective To explore and analyze the clinical efficacy and adverse reactions of total glucosides of paeony （TGP） and vitamin B2 in the treatment of recurrent aphthous ulcers （RAU）. Methods 120 patients of RAU were randomly divided into TGP group and vitamin B2 group, 60 cases in each group. The TGP group received TGP capsules after meals, three times a day, 0.6g/d. ＂Vitamin B2 group received vitamin B2 tablets, three times a day, 5mg/d, 8 weeks for one course. The ulcer change, visual analogue scale （VAS） and efficacy were observed. Results After treatment, the VAS scores were significantly reduced in two groups （P〈0.05） , and the above indicators of TGP group were better than vitamin B2 group （P〈0.05） .The total efficacy in TGP group was higher than that in vitamin B2 group （P〈0.05） . There was minor adverse reactions in TGP group and no significant adverse reactions in vitamin B2 group.Conclusion TGP has good efficacy and safety in the treatment of recurrent aphthous ulcers. The TGP has significant effect than that of vitamin B2.

关 键 词：白芍总苷 维生素B2 复发性阿弗他溃疡 疗效 

分 类 号：R781.5[医药卫生—口腔医学]