肿瘤干细胞标志物Lgr5和CD44在食管癌中的表达及临床病理意义  

Expression of tumor stem cell markers Lgr5 and CD44 in esophageal carcinoma and its clinical significance

作　　者：赵海菲[1] 周建文[1] 徐益平[1] 

机构地区：[1]杭州市肿瘤医院病理科

出　　处：《中国生化药物杂志》2017年第1期296-297,301,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 研究分析肿瘤干细胞标志物Lgr5和CD44在食管癌中的表达及临床病理意义。方法 选取诊断为食管癌的患者共108例,其中Ⅰ期29例,Ⅱ期35例,Ⅲ期40例,Ⅳ期4例。制作肿瘤标本,染色后分析食管癌组织中Lgr5和CD44的表达水平及其与临床特征的关系。结果 食管癌组织中Lgr5和CD44的表达与临床分期有关,分期越晚,Lgr5和CD44的高表达率有升高趋势,但经χ2检验显示,差异不具统计学意义。根据Spearman相关分析,Lgr5以及CD44升高均与食管癌无相关关系。结论 Lgr5和CD44在食管癌组织中呈高表达,但其与临床分期的关系尚待讨论。Objective To analyze the expressions of tumor stem cell markers Lgr5 and CD44 in esophageal carcinoma and its clinical pathological significance.Methods A total of 108 cases of patients with esophageal cancer, 35 cases of stage II, 40 cases of stage III, 4 cases of stage IV. After tumor specimens were stained, the expressions of Lgr5 and CD44 in esophageal cancer tissue were detected and its relationship with the clinical features were analyzed.ResultS There were relations between expressions of Lgr5 and CD44 in esophageal cancer tissue and clinical staging, the later the stageing, the higher expression rate of Lgr5 and CD44, but there was no significant differece with Chi-square test. The Spearman correlation analysis showed there was no correlation between Lgr5 or CD44 and esophageal cancer condition. Conclusion CD44 and Lgr5 are highly expressed in esophageal cancer tissue, but the correlation between CD44 and Lgr5 expression and esophageal cancer condition is uncertain.

关 键 词：LGR5 CD44 食管癌 相关性 

分 类 号：R735.1[医药卫生—肿瘤]