脑蛋白水解物在儿科临床中的应用  

Application of cerebrolysin in pediatric clinic

作　　者：赵明倩 麦泳瑶 刘毅[4] 邓湘俊 陈琳[6] 程国华[3] 王霆 

机构地区：[1]广州一品红制药有限公司,广东广州510760 [2]广东省生化制剂工程中心,广东广州510760 [3]暨南大学药学院,广东广州510632 [4]首都儿科研究所附属儿童医院药学部,北京100021 [5]中南大学湘雅药学院,湖南长沙410083 [6]暨南大学附属第一医院药学部,广东广州510632

出　　处：《中国生化药物杂志》2017年第1期315-318,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：脑蛋白水解物是从猪脑组织中提取的具有器官特异性的氨基酸混合物水溶液,主要由85%游离状态氨基酸以及15%小分子肽组成。脑蛋白水解物能增加脑内氨基酸代谢及葡萄糖的转运,提高细胞抗缺氧能力,增强大脑对各类应激、损伤等恶性刺激的抵抗力;又能促进突触形成、诱导神经元分化,逆转脑损伤。脑蛋白水解物因其疗效和安全性在儿科临床中得到广泛应用,主要用于治疗新生儿缺氧缺血性脑病、小儿脑瘫、多动症、言语沟通障碍等儿童疾病。患儿经脑蛋白水解物治疗后临床症状得到不同程度改善,如意识恢复、理解记忆力增强、运动能力改善等。脑蛋白水解物治疗不仅能提高患儿痊愈率,还能减少后遗症的发生。本文对近年来国内外有关脑蛋白水解物在儿科临床应用及相关临床前研究作一综述,为临床医生应用脑蛋白水解物治疗儿科疾病提供更多依据。Cerebrolysin is an aqueous mixture of amino acids extracted from porcine brain, and mainly composed of 85% free amino acids and 15% small peptides. Cerebrolysin increase the metabolism of amino acids and glucose transport in the brain, improve the anti-anoxia ability of cells, and to enhance the brain＇s resistance to various types of malignant stimulation like stress and damage. Cerebrolysin can also promote synapse formation, induce neuronal differentiation, and help reverse brain injury. Because of its efficacy and safety, cerebrolysin has been widely used in the pediatric clinical practice, and primarily to treat neonatal hypoxic ischemic encephalopathy, childcerebral palsy, hyperactivity disorder, speech communication disorders, etc.The clinical sjonptoms were improved to some extent after the treatment of cerebrolysin. The recovery of consciousness, enhancement of comprehensionand memory, and improvement of the extremity motor function were observed. The treatment of cerebrolysincan not only enhance the cure rate, but also reduce the incidence of sequelae. This paper systematically summarized the clinical application of cerebrolysin in the pediatric population and relevant preclinical studies, to provide more guidance for clinical application of cerebrolysin in the treatment of pediatric diseases.

关 键 词：脑蛋白水解物 临床应用 新生儿缺氧缺血性脑病 小儿脑瘫 联合用药 

分 类 号：R748[医药卫生—神经病学与精神病学] R722.1[医药卫生—临床医学]