舒肝解郁胶囊对抑郁症患者糖脂代谢与睡眠及体质量的影响  

Effects of Shuganjieyu capsule of plasma glucose and lipid metabolism and sleep and body weight in depression

作　　者：齐文耀 汤义平[1] 陈倩倩[1] 曹敏敏[1] 

机构地区：[1]台州市第二人民医院心身科

出　　处：《中国生化药物杂志》2017年第2期84-86,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨舒肝解郁胶囊对抑郁症患者糖脂代谢与睡眠及体质量的影响。方法选择2013年7月～2016年7月台州市第二人民医院接诊的90例抑郁症患者,通过随机数表法分为观察组（n=45）和对照组（n=45）。对照组给予西酞普兰治疗,观察组使用舒肝解郁胶囊治疗。比较2组糖脂代谢、睡眠情况、体质量及临床疗效。结果治疗后,观察组空腹血糖（FBG）、餐后2 h血糖（2 hPG）、甘油三酯（TG）、总胆固醇（TC）比对照组低（均P〈0.05）;观察组睡眠状况自评量表（SRSS）、匹兹堡睡眠质量指数（PSQI）低于对照组（均P〈0.05）;观察组体质量、体重指数低于对照组（均P〈0.05）;观察组总有效率95.56%（43/45）高于对照组77.78%（35/45）（P〈0.05）;观察组不良反应发生率20.00%（9/45）低于对照组46.67%（21/45）（P〈0.05）。结论在抑郁症患者中应用舒肝解郁胶囊效果显著,有利于保持患者糖脂代谢、体重平稳,并改善睡眠质量及临床症状,安全性高。Objective To study effects of shuganjieyu capsule of plasma glucose and lipid metabolism and sleep and body weight in patients with depression.Methods 90 patients of depression who received therapy from July 2013 to July 2016 in our hospital were selected.According to random number table,those patients were divided into the observation group（n=45） and the control group（n=45）.The control group was treated with citalopram,while the observation group was treated with shuganjieyu capsule,then glucose and lipid metabolism,sleep,weight and clinical curative effect were compared.Results After treatment,the fasting blood glucose（FBG）,postprandial 2h blood glucose（2 h PG）,triacylglycerol（TG）,total cholesterol（TC） in the observation group were lower than the control group（all P〈0.05）,the sleep state self rating scale（SRSS） and the Pittsburgh sleep quality index（PSQI） in the observation group were lower than the control group（all P〈0.05）.The body weight and body mass index in the observation group were lower than the control group（all P〈0.05）.The total effective rate in the observation group 95.56%（43/45） was higher than the control group 77.78%（35/45）（P〈0.05）;the incidence of adverse reactions in observation group 20.00%（9/45） was lower the control group46.67%（21/45）（P〈0.05）.Conclusion Shuganjieyu capsule is well for depression,which can conducive to maintaining glucose and lipid metabolism,weight stability,and improve sleep quality and clinical symptoms,and high security,it＇s worthy of application and promotion.

关 键 词：抑郁症 舒肝解郁胶囊 糖脂代谢 睡眠 体质量 

分 类 号：R749.41[医药卫生—神经病学与精神病学]