观察利培酮口腔崩解片联合奥沙西泮治疗精神分裂症的疗效及不良反应  

Observation efficacy and side effects of risperidone orally disintegrating tablets combined with oxazepam in schizophrenia

作　　者：何燕 张敏桥 韩亚丽 蒋达平 

机构地区：[1]浙江省宁波市象山县第三人民医院精神科

出　　处：《中国生化药物杂志》2017年第2期202-204,208,共4页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨利培酮口腔崩解片联合奥沙西泮治疗精神分裂症的疗效及不良反应。方法选取63例精神分裂症患者,按照入院顺序进行分组。分为对照组（31例）和观察组（32例）,分别给予氯丙嗪＋阿普唑仑治疗和利培酮口腔崩解片＋奥沙西泮治疗。观察2组治疗后的阳性与阴性症状量表（PANSS）评分、生活质量SF-36健康问卷评分和治疗前后的日常生活能力量表（ADL）评分,进行疗效判定和不良反应记录,并进行比较。结果经不同的治疗后进行PANSS评分和比较,观察组不同症状评分以及一般精神病理和总分均显著低于对照组,差异有统计学意义（P〈0.05）;治疗后2组的ADL评分与本组治疗前比较均明显上升,且治疗后的观察组评分显著高于对照组,差异有统计学意义（P〈0.05）;经疗效判定,观察组有效率为93.75%,显著高于对照组的77.42%,差异有统计学意义（P〈0.05）;治疗后1个月进行生活质量SF-36健康问卷评分和比较,观察组各项得分均显著高于对照组,差异有统计学意义（P〈0.05）;2组均出现一定的不良反应,观察组不良反应发生率为9.38%,显著低于对照组的45.15%,差异有统计学意义（P〈0.05）。结论精神分裂症实施利培酮口腔崩解片联合奥沙西泮治疗效果显著,可以更好的改善患者的临床症状,提高患者的日常生活能力和生活质量。且有效减少各种不良反应的出现,是一种安全高效的治疗方案。Objective To investigate the efficacy and adverse reactions of risperidone orally disintegrating tablets joint oxazepam in the treatment of schizophrenia.Methods 63 patients with schizophrenia were selected and divided into two groups according to the order of admission Divided into the control group（31 cases） and observation group（32 cases）,were treated with chlorpromazine ＋ alprazolam and risperidone orally disintegrating tablets ＋ oxazepam.The two groups after treatment PANSS score,quality of life SF-36 health questionnaire score and ADL score before and after treatment,curative effect and adverse reactions were recorded and compared.Results The different PANSS score after treatment and compared,the observation group with different symptoms score and general psychopathology scores are significantly lower than the control group,the difference was statistically significant（P〈0.05）,the two groups after treatment ADL score compared with those before treatment were significantly increased,and the score of the observation group after treatment was significantly higher than the control group,the difference was statistically significant（P〈0.05）,the curative effect of observation group was 93.75%,significantly higher than the control group 77.42%,the difference was statistically significant（P〈0.05）,quality of life questionnaire SF-36 score and one months after treatment,observation group scores were significantly higher than those in control group,the difference was statistically significant（P〈0.05）,there were some adverse reactions in the two groups,the adverse reaction rate of observation group was 9.38%,significantly lower than 45.15% of the control group,the difference was statistically significant（P〈0.05）.Conclusion The implementation of schizophrenia risperidone orally disintegrating tablets oxazepam effect significantly,can better improve the clinical symptoms of patients,improve the patient＇s ability of daily life and quality of life.It can effectively reduce the occu

关 键 词：精神分裂症 利培酮口腔崩解片 奥沙西泮 联合 不良反应 

分 类 号：R749.3[医药卫生—神经病学与精神病学]