卡芬太尼的合成方法研究进展  

Research progress in the synthesis of carfentanil

作　　者：齐志敏[1] 谢艳蓉[1] 万宁[1] 张邦乐[1] 

机构地区：[1]第四军医大学药学院,西安710032

出　　处：《西北药学杂志》2017年第2期238-241,共4页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:21342017);校精英人才"青年英才支持计划"与科技发展研究基金项目(编号:2016XC078)

摘　　要：目的探讨卡芬太尼合成方法的研究进展,以期为该类药物的进一步应用和新型高效药物的研发提供借鉴。方法以芬太尼类衍生物药物研发为线索,查阅了1976年至今的国内外文献,对卡芬太尼的合成进展进行综述。结果卡芬太尼的合成主要有3条路线,分别为以1-苄基-4-哌啶酮、1-苯乙基-4-哌啶酮和N-Boc保护哌啶酮为原料的合成方法。结论卡芬太尼工艺路线的比较和分析为卡芬太尼衍生物的合成、生产以及工艺选择提供了依据。To review the research development of synthetic method of carfentanilin in order to develop a new efficient drugand provide further application of this kind of drugs. Focused on the drug development of fentanyl derivatives, the litera-tures about the synthetic method of carfentanil were reviewed, which were reported by various research groups since 1976.The preparation of crafentanil included 3 synthetic methods, by using 1-benzyl-4-piperidone, 1-phenethyl-4-pipafidone and N-boc-protected piperidone as starting materials^respectively. The comparison and analysis of the above synthetic methods canprovide the suggestion on the preparation of carfentanil and its derivatiyes, as well as the optimization of production process.

关 键 词：卡芬太尼 合成方法 镇痛药 麻醉药 

分 类 号：R914[医药卫生—药物化学]