青少年肌阵挛癫痫的小脑半球功能连接分析  

Analysis of cerebello-cerebral functional connectivity in juvenile myoclonic epilepsy

作　　者：贾晓燕[1] 叶国凤[1] 蒋思思[1] 何忠琼 罗程[1] 尧德中[1] 

机构地区：[1]电子科技大学,四川成都610054

出　　处：《四川精神卫生》2017年第1期32-36,共5页Sichuan Mental Health

基　　金：国家自然科学基金(81271547)

摘　　要：目的探讨青少年肌阵挛癫痫(JME)患者的小脑半球与大脑的功能连接特征。方法采用横断面研究方法,选取2014年3月-2015年12月在成都市新华社区卫生服务中心和成都市第一人民医院就诊的JME患者25例(患者组),同期纳入26名健康对照者(对照组)。利用GE 3.0T磁共振采集两组静息态功能磁共振(fMRI)图像,对双侧小脑半球的18个感兴趣区域(ROI)分别进行与大脑的功能连接,分析JME患者各个感兴趣区与大脑功能连接的改变。结果①两组年龄、性别差异均无统计学意义(P均>0.05)。②JME患者的小脑半球与颞、枕叶功能连接高于健康对照组,而与额叶、默认模式网络(DMN)以及运动相关脑区的功能连接低于健康对照组,差异均有统计学意义(P均<0.05)。结论小脑与额叶的功能连接降低,可能与临床上JME患者额叶高波幅放电有关,同时小脑与运动相关脑区的功能连接降低可能与JME患者的运动功能异常有关。Objective To investigate characteristics of cerebello - cerebral functional connectivity in juvenile myoclonic epilepsy（ JME） . Methods A cross - sectional study, including 25 patients of Chengdu Xinhua Community Health Service Center and Chengdu First Peopled Hospital from March 2014 to December 2015, and 26 healthy controls, were performed. Resting - state functional magnetic resonance imaging of were scanned by GE 3. 0T Magnetic Resonance for all subjects. Functional connectivity was calculated between 18 regions of interest （ROI） of the bilateral cerebellar hemisphere and cerebrum,and then was evaluated for each ROI respectively. Results （I） There was no significant difference in age or gender between the two groups （ P 〉0. 05 ） . ② The functional connectivity between the cerebellar hemisphere and the temporal lobe, occipital lobe of JME were higher than healthy control, while the functional connectivity between the cerebellar hemisphere and frontal lobe, default mode network, motor - related brain areas of JME were lower than healthy control. All the differences were statistically significant （P 〈 0. 0 5 ）. Conclusion The decreased functional connectivity in frontal lobe and cerebellum would be associated with the front central region discharge with high amplitude in the clinic and the decreased functional connectivity between the cerebellum and the motor - related brain areas is correlated with the motor dysfunction of JME.

关 键 词：青少年肌阵挛癫痫 小脑半球 静息态功能磁共振 功能连接 

分 类 号：R742.1[医药卫生—神经病学与精神病学]