血清鳞状细胞癌抗原在宫颈鳞癌中的应用价值  

Application of Serum SCC in Cervical Squamous Cell Carcinoma

作　　者：温东瑜 熊小琴[1] 辛玉宏[1] 

机构地区：[1]广东省江门市人民医院,广东江门529000

出　　处：《中国医学创新》2017年第5期36-39,共4页Medical Innovation of China

摘　　要：目的:探讨鳞状细胞癌抗原(SCC)在宫颈鳞癌(CSCC)中的应用价值。方法:将2010年1月-2016年9月本院收治的62例CSCC患者归为A组、65例宫颈上皮内瘤变Ⅲ级(CINⅢ)为B组、62例健康体检者为C组,分别检测三组血清SCC和其他常用肿瘤指标CEA、CA125、CA199,比较三组各指标以及CSCC不同病理分级及临床分期之间的的差异,同时分析其对CSCC诊断的价值。结果:(1)三组患者CEA、CA125和CA199比较差异均无统计学意义(P>0.05),A组SCC为(14.400±3.560)μg/L,明显高于B组(0.860±0.088)μg/L和C组(0.730±0.040)μg/L,比较差异有统计学意义(P<0.05),B、C组SCC比较差异无统计学意义(P>0.05)。(2)CSCC患者不同病理组织学分级、临床分期以及Ⅱ期单独比较中,CEA、CA125和CA199比较差异均无统计学意义(P>0.05),SCC比较差异有统计学意义(P<0.05),且随着恶性程度的升高而增加。(3)血清SCC与CSCC有正相关关系,相关系数为0.66,其余指标相关系数较低。(4)以SCC>1.45μg/L作为CSCC诊断指标,其灵敏度和特异度为83.9%、96.1%,约登指数为0.80。结论:血清SCC可作为诊断CSCC检测标志物,对预测肿瘤恶性程度有一定意义,其余三项常用指标诊断价值不高。Objective： To discuss the application of SCC in CSCC.Method： 62 patients with CSCC in our hospital from January 2010 to September 2016 were selected as group A, 65 patients with CINⅢ were selected as group B, 62 healthy subjects were selected as the group C.Serum SCC, CEA, CA125 and CA199 of three groups were detected, then compared the differences of the indicators among three groups and analyzed the value in diagnosis.Result： （ 1 ） There were no significant differences in three groups with CEA, CA125 and CA199.SCC in group A was （ 14.400 ± 3.560 ） μ g/L higher than group B （ 0.860 ± 0.088 ） μg/L and group C （ 0.730 ± 0.040 ） μ g/L, the difference was statistically significant （ P〈0.05 ）, but there was no significant difference between group B and group C （P〉0.05 ） . （ 2 ） There were significant differences in SCC between patients with different histological grade, clinical stage and CSCC of phaseⅡ, and increased with the degree of malignancy, but other three indicators had no significant difference （P〉0.05 ） . （ 3 ） SCC had positive correlation with CSCC （ P〈0.05 ）, the correlation coefficient was 0.66, the other three indicators were low. （ 4 ） With SCC〉1.45 pL g/L as diagnostic critical value, the sensitivity and specificity were 83.9%, 96.1%, Youden＇s index was 0.80.Conclusion： SCC can be used as detection markers for CSCC, it has certainly significance in predicting the degree of malignancy, the Other three indicators have no high value in diagnosis.

关 键 词：鳞状细胞癌抗原 CEA CA125 CA199 宫颈鳞癌 

分 类 号：R737.33[医药卫生—肿瘤]