血小板参数在乳腺癌患者早期诊断中的价值  

Values of platelet parameters detection in early diagnosis of breast cancer

作　　者：王海燕[1] 钟田花[1] 卢春敏[1] 黄艳芬[1] 穆小萍[1] 

机构地区：[1]广东省妇幼保健院检验科,广州510000

出　　处：《重庆医学》2017年第6期780-781,785,共3页Chongqing medicine

摘　　要：目的探讨血小板参数测定在乳腺癌早期诊断中的应用价值。方法回顾性分析2015年1-12月该院收治的103例乳腺癌患者与117例纤维腺瘤患者入院24h内的静脉血血小板参数,包括血小板计数(PLT)、血小板压积(PCT)、平均血小板体积(MPV)、平均血小板内容物浓度(MPC)、平均血小板内容物含量(MPM)、血小板分布宽度(PDW),与100例同期健康体检人群作对照组进行比较,并绘制ROC曲线评价血小板各参数的诊断效能。结果与对照组相比,纤维腺瘤组和乳腺癌组的PLT、PCT显著增高(P<0.01),MPC、MPM、PDW显著降低(P<0.01),MPV差异无统计学意义(P>0.05);与纤维腺瘤组相比,乳腺癌组的MPC明显降低,差异有统计学意义(P<0.01)。MPC用于诊断乳腺癌的ROC曲线下面积最高(AUC=0.841),当诊断临界值为249.5g/L时,敏感性为82.5%,特异度为73.6%。结论血小板参数的检测,尤其是MPC,对乳腺癌的早期诊断具有一定的应用价值。Objective To explore the application value of platelet parameters detection in early diagnosis of breast cancer.Methods Platelet parameters of intravenous blood from 103 breast cancer patients and 117 fibroadenoma patients within 24 hours of admission between January 2015 and December 2015 were collected and retrospectively analyzed,including platelet count（PLT）,plateletcrit（PCT）,mean platelet volume（MPV）,mean platelet component concentration（MPC）,mean platelet component mass（MPM）,platelet distribution width（PDW）,and compared with control group of 100 healthy women.The diagnostic efficiency of platelet parameters were assessed using receiver operating characteristic（ROC）curve.Results PLT and PCT in breast cancer group and fibroadenoma group were significantly higher than those in control group（P〈0.01）;MPC,PMM and PDW were significantly lower than those in control group（P〈0.01）;MPV had no significant statistically difference（P〈0.05）.The levels of MPC in breast cancer group were obviously lower than that in fibroadenoma group（P〈0.01）.The diagnostic efficiency of MPC in breast cancer had the highest area under curve（AUC=0.835）.While the cutoff value of MPC was 249.5g/L,sensitivity and specificity were 82.5% and 73.6%,respectively.Conclusion The detection of platelet parameters,especially MPC,have certain application value in early diagnosis of breast cancer.

关 键 词：乳腺肿瘤 血小板 平均血小板内容物浓度 

分 类 号：R737.9[医药卫生—肿瘤]